Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.

Bibliographic Details
Main Authors:	Meaghan Boileau, Margret Shirinian, Tenzin Gayden, Ashot S. Harutyunyan, Carol C. L. Chen, Leonie G. Mikael, Heather M. Duncan, Andrea L. Neumann, Patricia Arreba-Tutusaus, Nicolas De Jay, Michele Zeinieh, Katya Rossokhata, Yelu Zhang, Hamid Nikbakht, Carine Mouawad, Radwan Massoud, Felice Frey, Rihab Nasr, Jean El Cheikh, Marwan El Sabban, Claudia L. Kleinman, Rami Mahfouz, Mark D. Minden, Nada Jabado, Ali Bazarbachi, Kolja Eppert
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10705-z

id	doaj-c65cab72003240578c7b04815c5c955e
record_format	Article
spelling	doaj-c65cab72003240578c7b04815c5c955e2021-05-11T12:36:38ZengNature Publishing GroupNature Communications2041-17232019-06-0110111210.1038/s41467-019-10705-zMutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressivenessMeaghan Boileau0Margret Shirinian1Tenzin Gayden2Ashot S. Harutyunyan3Carol C. L. Chen4Leonie G. Mikael5Heather M. Duncan6Andrea L. Neumann7Patricia Arreba-Tutusaus8Nicolas De Jay9Michele Zeinieh10Katya Rossokhata11Yelu Zhang12Hamid Nikbakht13Carine Mouawad14Radwan Massoud15Felice Frey16Rihab Nasr17Jean El Cheikh18Marwan El Sabban19Claudia L. Kleinman20Rami Mahfouz21Mark D. Minden22Nada Jabado23Ali Bazarbachi24Kolja Eppert25Division of Experimental Medicine, McGill University and McGill University Heath Centre Research InstituteDepartment of Experimental Pathology, Immunology, and Microbiology, American University of BeirutDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Pediatrics, McGill University and McGill University Heath Centre Research InstituteDivision of Experimental Medicine, McGill University and McGill University Heath Centre Research InstituteResearch Institute of the McGill University Health Centre and McGill UniversityResearch Institute of the McGill University Health Centre and McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityResearch Institute of the McGill University Health Centre and McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Experimental Pathology, Immunology, and Microbiology, American University of BeirutDepartment of Internal Medicine, American University of BeirutDepartment of Experimental Pathology, Immunology, and Microbiology, American University of BeirutDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of BeirutDepartment of Internal Medicine, American University of BeirutDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of BeirutDepartment of Human Genetics, McGill UniversityDepartment of Pathology and Laboratory Medicine, American University of BeirutPrincess Margaret Cancer Centre, University Health Network, University of TorontoDepartment of Human Genetics, McGill UniversityDepartment of Internal Medicine, American University of BeirutDepartment of Pediatrics, McGill University and McGill University Heath Centre Research InstituteThe role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.https://doi.org/10.1038/s41467-019-10705-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert
spellingShingle	Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness Nature Communications
author_facet	Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert
author_sort	Meaghan Boileau
title	Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
title_short	Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
title_full	Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
title_fullStr	Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
title_full_unstemmed	Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
title_sort	mutant h3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.
url	https://doi.org/10.1038/s41467-019-10705-z
work_keys_str_mv	AT meaghanboileau mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT margretshirinian mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT tenzingayden mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT ashotsharutyunyan mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT carolclchen mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT leoniegmikael mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT heathermduncan mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT andrealneumann mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT patriciaarrebatutusaus mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT nicolasdejay mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT michelezeinieh mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT katyarossokhata mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT yeluzhang mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT hamidnikbakht mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT carinemouawad mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT radwanmassoud mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT felicefrey mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT rihabnasr mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT jeanelcheikh mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT marwanelsabban mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT claudialkleinman mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT ramimahfouz mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT markdminden mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT nadajabado mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT alibazarbachi mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness AT koljaeppert mutanth3histonesdrivehumanpreleukemichematopoieticstemcellexpansionandpromoteleukemicaggressiveness
_version_	1721444513904328704

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

Similar Items