Gradient light interference microscopy for 3D imaging of unlabeled specimens

Gradient light interference microscopy for 3D imaging of unlabeled specimens

Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.

Bibliographic Details
Main Authors: Tan H. Nguyen, Mikhail E. Kandel, Marcello Rubessa, Matthew B. Wheeler, Gabriel Popescu
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00190-7
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spelling doaj-c65e37646af14d50945de891b9a135e72021-01-31T12:45:59ZengNature Publishing GroupNature Communications2041-17232017-08-01811910.1038/s41467-017-00190-7Gradient light interference microscopy for 3D imaging of unlabeled specimensTan H. Nguyen0Mikhail E. Kandel1Marcello Rubessa2Matthew B. Wheeler3Gabriel Popescu4Department of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-ChampaignCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-ChampaignDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignChallenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.https://doi.org/10.1038/s41467-017-00190-7
collection DOAJ
language English
format Article
sources DOAJ
author Tan H. Nguyen
Mikhail E. Kandel
Marcello Rubessa
Matthew B. Wheeler
Gabriel Popescu
spellingShingle Tan H. Nguyen
Mikhail E. Kandel
Marcello Rubessa
Matthew B. Wheeler
Gabriel Popescu
Gradient light interference microscopy for 3D imaging of unlabeled specimens
Nature Communications
author_facet Tan H. Nguyen
Mikhail E. Kandel
Marcello Rubessa
Matthew B. Wheeler
Gabriel Popescu
author_sort Tan H. Nguyen
title Gradient light interference microscopy for 3D imaging of unlabeled specimens
title_short Gradient light interference microscopy for 3D imaging of unlabeled specimens
title_full Gradient light interference microscopy for 3D imaging of unlabeled specimens
title_fullStr Gradient light interference microscopy for 3D imaging of unlabeled specimens
title_full_unstemmed Gradient light interference microscopy for 3D imaging of unlabeled specimens
title_sort gradient light interference microscopy for 3d imaging of unlabeled specimens
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.
url https://doi.org/10.1038/s41467-017-00190-7
work_keys_str_mv AT tanhnguyen gradientlightinterferencemicroscopyfor3dimagingofunlabeledspecimens
AT mikhailekandel gradientlightinterferencemicroscopyfor3dimagingofunlabeledspecimens
AT marcellorubessa gradientlightinterferencemicroscopyfor3dimagingofunlabeledspecimens
AT matthewbwheeler gradientlightinterferencemicroscopyfor3dimagingofunlabeledspecimens
AT gabrielpopescu gradientlightinterferencemicroscopyfor3dimagingofunlabeledspecimens
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