Osteopontin-Enhanced Autophagy Attenuates Early Brain Injury via FAK–ERK Pathway and Improves Long-Term Outcome after Subarachnoid Hemorrhage in Rats

Osteopontin-Enhanced Autophagy Attenuates Early Brain Injury via FAK–ERK Pathway and Improves Long-Term Outcome after Subarachnoid Hemorrhage in Rats

Osteopontin (OPN) enhances autophagy, reduces apoptosis, and attenuates early brain injury (EBI) after a subarachnoid hemorrhage (SAH). A total of 87 Sprague−Dawley rats were subjected to sham or SAH operations to further investigate the signaling pathway involved in osteopontin-enhanced a...

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Bibliographic Details
Main Authors: Chengmei Sun, Budbazar Enkhjargal, Cesar Reis, Tongyu Zhang, Qiquan Zhu, Keren Zhou, Zhiyi Xie, Lingyun Wu, Jiping Tang, Xiaodan Jiang, John H. Zhang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
osteopontin
subarachnoid hemorrhage
autophagy
hippocampal injury
delayed brain injury
Online Access:https://www.mdpi.com/2073-4409/8/9/980

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