Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice
Quercetin 3-O-sophoroside (Q3OS) was isolated and identified from Hibiscus rosa-sinensis Linn. (HRS) for the first time. Although Q3OS is common glycosides, its therapeutic potential and mechanism of action against Alzheimer’s disease (AD) have rarely been reported.The results demonstrated that Q3OS...
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doaj-c6605a0d2678477c97c045af0fb00c4a2021-04-30T07:20:13ZengElsevierJournal of Functional Foods1756-46462021-01-0176104291Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in miceHuimin Shen0Yilin Zheng1Ruiqian Chen2Xiaohua Huang3Ganggang Shi4Department of Neurology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, ChinaDepartment of Pharmacy, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, Guangdong, ChinaDepartment of Networks Center, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, ChinaDepartment of Pediatrics, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, ChinaDepartment of Pharmacology, Shantou University Medical College, Shantou 515041, Guangdong, China; Corresponding author.Quercetin 3-O-sophoroside (Q3OS) was isolated and identified from Hibiscus rosa-sinensis Linn. (HRS) for the first time. Although Q3OS is common glycosides, its therapeutic potential and mechanism of action against Alzheimer’s disease (AD) have rarely been reported.The results demonstrated that Q3OS treatment effectively ameliorated learning and memory impairment in mice with scopolamine (SCOP)-induced cognitive dysfunction by using the Morris water maze test. Nissl staining results revealed that Q3OS administration blocked neuronal loss in the hippocampal CA1 region. Immunohistochemistry and western blot results also indicated that Q3OS reversed the SCOP-induced decrease in ChAT expression, increase in AChE expression, and decrease in ACh.These findings suggested that Q3OS from HRS could be potentially used to prevent and treat AD, by exerting neuroprotective effects and these effects could be in response to its modification of the cholinergic system function. HRS can be potentially used as a neuroprotective nutrient in the prevention of AD.http://www.sciencedirect.com/science/article/pii/S1756464620305156Alzheimer’s diseaseHibiscus rosa-sinensis Linn.Quercetin 3-O-sophorosideScopolamineSpatial cognitionCholinergic system function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huimin Shen Yilin Zheng Ruiqian Chen Xiaohua Huang Ganggang Shi |
spellingShingle |
Huimin Shen Yilin Zheng Ruiqian Chen Xiaohua Huang Ganggang Shi Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice Journal of Functional Foods Alzheimer’s disease Hibiscus rosa-sinensis Linn. Quercetin 3-O-sophoroside Scopolamine Spatial cognition Cholinergic system function |
author_facet |
Huimin Shen Yilin Zheng Ruiqian Chen Xiaohua Huang Ganggang Shi |
author_sort |
Huimin Shen |
title |
Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice |
title_short |
Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice |
title_full |
Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice |
title_fullStr |
Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice |
title_full_unstemmed |
Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice |
title_sort |
neuroprotective effects of quercetin 3-o-sophoroside from hibiscus rosa-sinensis linn. on scopolamine-induced amnesia in mice |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2021-01-01 |
description |
Quercetin 3-O-sophoroside (Q3OS) was isolated and identified from Hibiscus rosa-sinensis Linn. (HRS) for the first time. Although Q3OS is common glycosides, its therapeutic potential and mechanism of action against Alzheimer’s disease (AD) have rarely been reported.The results demonstrated that Q3OS treatment effectively ameliorated learning and memory impairment in mice with scopolamine (SCOP)-induced cognitive dysfunction by using the Morris water maze test. Nissl staining results revealed that Q3OS administration blocked neuronal loss in the hippocampal CA1 region. Immunohistochemistry and western blot results also indicated that Q3OS reversed the SCOP-induced decrease in ChAT expression, increase in AChE expression, and decrease in ACh.These findings suggested that Q3OS from HRS could be potentially used to prevent and treat AD, by exerting neuroprotective effects and these effects could be in response to its modification of the cholinergic system function. HRS can be potentially used as a neuroprotective nutrient in the prevention of AD. |
topic |
Alzheimer’s disease Hibiscus rosa-sinensis Linn. Quercetin 3-O-sophoroside Scopolamine Spatial cognition Cholinergic system function |
url |
http://www.sciencedirect.com/science/article/pii/S1756464620305156 |
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