Assessment of the influence of direct tobacco smoke on infection and active TB management.
Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays...
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doaj-c66b12e65cce4b679bf0fb79160255522020-11-25T01:31:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018299810.1371/journal.pone.0182998Assessment of the influence of direct tobacco smoke on infection and active TB management.Neus AltetIrene LatorreMaría Ángeles Jiménez-FuentesJosé MaldonadoIsrael MolinaYoel González-DíazCelia MilàEsther García-GarcíaBeatriz MurielRaquel Villar-HernándezMaisem LaabeiAndromeda-Celeste GómezPere GodoyMaria Luiza de Souza-GalvãoSegismundo SolanoCarlos A Jiménez-RuizJose DomínguezPII Smoking SEPAR Working GroupSmoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs).In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs.A total of 525 participants were studied: (i) 175 active pulmonary TB patients and (ii) 350 individuals coming from contact tracing studies, 41 of whom were secondary TB cases. Clinical, radiological and microbiological data were collected. T-SPOT.TB and QFN-G-IT were processed according manufacturer's instructions.In smoking patients with active TB, QFN-G-IT (34.4%) and T-SPOT.TB (19.5%) had high frequencies of negative results. In addition, by means of an unconditional logistic regression, smoking was a main factor associated with IGRAs' false-negative results (aOR: 3.35; 95%CI:1.47-7.61; p<0.05). Smoking patients with active TB presented a high probability of having cavitary lesions (aOR: 1.88; 95%CI:1.02-3.46;p<0.05). Mean culture negativization (months) ± standard deviation (SD) was higher in smokers than in non-smokers (2.47±1.3 versus 1.69±1.4). Latent TB infection (LTBI) was favored in smoking contacts, being a risk factor associated with infection (aOR: 11.57; 95%CI:5.97-22.41; p<0.00005). The IFN-γ response was significantly higher in non-smokers than in smokers. Smoking quantity and IFN-γ response analyzed by IGRAs were dose-dependent related.Smoking had a negative effect on radiological manifestations, delaying time of sputum conversion. Our data establish a link between tobacco smoking and TB due to a weakened IFN-γ response caused by direct tobacco smoke.http://europepmc.org/articles/PMC5570217?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes José Maldonado Israel Molina Yoel González-Díaz Celia Milà Esther García-García Beatriz Muriel Raquel Villar-Hernández Maisem Laabei Andromeda-Celeste Gómez Pere Godoy Maria Luiza de Souza-Galvão Segismundo Solano Carlos A Jiménez-Ruiz Jose Domínguez PII Smoking SEPAR Working Group |
spellingShingle |
Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes José Maldonado Israel Molina Yoel González-Díaz Celia Milà Esther García-García Beatriz Muriel Raquel Villar-Hernández Maisem Laabei Andromeda-Celeste Gómez Pere Godoy Maria Luiza de Souza-Galvão Segismundo Solano Carlos A Jiménez-Ruiz Jose Domínguez PII Smoking SEPAR Working Group Assessment of the influence of direct tobacco smoke on infection and active TB management. PLoS ONE |
author_facet |
Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes José Maldonado Israel Molina Yoel González-Díaz Celia Milà Esther García-García Beatriz Muriel Raquel Villar-Hernández Maisem Laabei Andromeda-Celeste Gómez Pere Godoy Maria Luiza de Souza-Galvão Segismundo Solano Carlos A Jiménez-Ruiz Jose Domínguez PII Smoking SEPAR Working Group |
author_sort |
Neus Altet |
title |
Assessment of the influence of direct tobacco smoke on infection and active TB management. |
title_short |
Assessment of the influence of direct tobacco smoke on infection and active TB management. |
title_full |
Assessment of the influence of direct tobacco smoke on infection and active TB management. |
title_fullStr |
Assessment of the influence of direct tobacco smoke on infection and active TB management. |
title_full_unstemmed |
Assessment of the influence of direct tobacco smoke on infection and active TB management. |
title_sort |
assessment of the influence of direct tobacco smoke on infection and active tb management. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs).In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs.A total of 525 participants were studied: (i) 175 active pulmonary TB patients and (ii) 350 individuals coming from contact tracing studies, 41 of whom were secondary TB cases. Clinical, radiological and microbiological data were collected. T-SPOT.TB and QFN-G-IT were processed according manufacturer's instructions.In smoking patients with active TB, QFN-G-IT (34.4%) and T-SPOT.TB (19.5%) had high frequencies of negative results. In addition, by means of an unconditional logistic regression, smoking was a main factor associated with IGRAs' false-negative results (aOR: 3.35; 95%CI:1.47-7.61; p<0.05). Smoking patients with active TB presented a high probability of having cavitary lesions (aOR: 1.88; 95%CI:1.02-3.46;p<0.05). Mean culture negativization (months) ± standard deviation (SD) was higher in smokers than in non-smokers (2.47±1.3 versus 1.69±1.4). Latent TB infection (LTBI) was favored in smoking contacts, being a risk factor associated with infection (aOR: 11.57; 95%CI:5.97-22.41; p<0.00005). The IFN-γ response was significantly higher in non-smokers than in smokers. Smoking quantity and IFN-γ response analyzed by IGRAs were dose-dependent related.Smoking had a negative effect on radiological manifestations, delaying time of sputum conversion. Our data establish a link between tobacco smoking and TB due to a weakened IFN-γ response caused by direct tobacco smoke. |
url |
http://europepmc.org/articles/PMC5570217?pdf=render |
work_keys_str_mv |
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