Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function
Small heterodimer partner (SHP, NR0B2) is identified as a unique orphan nuclear receptor that acts as a transcriptional repressor. SHP plays a crucial role in the control of various physiological processes and in several diseases by regulating the expression of disease-specific genes. Non-coding RNA...
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doaj-c682003a67cf4c0bb2a5670ded0bd65e2020-11-24T21:40:07ZengKenzPubNuclear Receptor Research2314-57142017-12-0141910.11131/2017/101312101312Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and FunctionYongfeng Song0Shan Lu1Jiajun Zhao2Li Wang3Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, ChinaGenesis Biotechnology, Trenton, NJ 08619, USADepartment of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, ChinaSmall heterodimer partner (SHP, NR0B2) is identified as a unique orphan nuclear receptor that acts as a transcriptional repressor. SHP plays a crucial role in the control of various physiological processes and in several diseases by regulating the expression of disease-specific genes. Non-coding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), are encoded of RNAs that are transcribed but not translated into proteins, which are involved in diverse developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified factors participating in the regulation of ncRNAs biogenesis and function. In this review, we summarize recent findings demonstrating a critical role of SHP as a transcriptional regulator of ncRNAs expression and function.http://www.kenzpub.com/journals/nurr/2017/101312/Nuclear receptorsSmall heterodimer partnernon-coding RNAs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongfeng Song Shan Lu Jiajun Zhao Li Wang |
spellingShingle |
Yongfeng Song Shan Lu Jiajun Zhao Li Wang Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function Nuclear Receptor Research Nuclear receptors Small heterodimer partner non-coding RNAs |
author_facet |
Yongfeng Song Shan Lu Jiajun Zhao Li Wang |
author_sort |
Yongfeng Song |
title |
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function |
title_short |
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function |
title_full |
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function |
title_fullStr |
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function |
title_full_unstemmed |
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function |
title_sort |
nuclear receptor shp: a critical regulator of mirna and lncrna expression and function |
publisher |
KenzPub |
series |
Nuclear Receptor Research |
issn |
2314-5714 |
publishDate |
2017-12-01 |
description |
Small heterodimer partner (SHP, NR0B2) is identified as a unique orphan nuclear receptor that acts as a transcriptional repressor. SHP plays a crucial role in the control of various physiological processes and in several diseases by regulating the expression of disease-specific genes. Non-coding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), are encoded of RNAs that are transcribed but not translated into proteins, which are involved in diverse developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified factors participating in the regulation of ncRNAs biogenesis and function. In this review, we summarize recent findings demonstrating a critical role of SHP as a transcriptional regulator of ncRNAs expression and function. |
topic |
Nuclear receptors Small heterodimer partner non-coding RNAs |
url |
http://www.kenzpub.com/journals/nurr/2017/101312/ |
work_keys_str_mv |
AT yongfengsong nuclearreceptorshpacriticalregulatorofmirnaandlncrnaexpressionandfunction AT shanlu nuclearreceptorshpacriticalregulatorofmirnaandlncrnaexpressionandfunction AT jiajunzhao nuclearreceptorshpacriticalregulatorofmirnaandlncrnaexpressionandfunction AT liwang nuclearreceptorshpacriticalregulatorofmirnaandlncrnaexpressionandfunction |
_version_ |
1725928099885875200 |