Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors

Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors

Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants born from infected mothers. ZIKV exhibits high neurotropism and promotes neuroinflammation and neuronal cell death. We have recently demonstra...

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Bibliographic Details
Main Authors: Isabella G. Olmo, Toniana G. Carvalho, Vivian V. Costa, Juliana Alves-Silva, Carolina Z. Ferrari, Tatiane C. Izidoro-Toledo, Juliana F. da Silva, Antonio L. Teixeira, Danielle G. Souza, Joao T. Marques, Mauro M. Teixeira, Luciene B. Vieira, Fabiola M. Ribeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
Zika virus
N-methyl-d-aspartate receptors
GluN2B
tumor necrosis factor-α
interleukin-1β
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01016/full

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