Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts
Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial, antioxidant, among others. However, these properties in peel have been poorly explored. Aims: Evaluate the wound healing activity induced by an incision wound mode...
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Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA)
2016-10-01
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Online Access: | http://jppres.com/jppres/pdf/vol4/jppres16.124_4.5.165.pdf |
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doaj-c682a8b4947c4117ab5775131ef40d622020-11-24T21:22:49ZengAcademic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA)Journal of Pharmacy & Pharmacognosy Research0719-42502016-10-0145165173Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extractsEduardo Padilla-Camberos0José M. Flores-Fernández1Alejandro A. Canales-Aguirre2Carla P. Barragán-Álvarez3Yanet Gutiérrez-Mercado4Eugenia Lugo-Cervantes5Unidad de Biotecnología Medica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Avenida Normalistas 800, Col. Colinas de la Normal, 44270. Guadalajara, Jalisco, México.Departamento de Investigación. Tecnológico de Estudios Superiores de Villa Guerrero, Carretera Federal Toluca-Ixtapan de la Sal, Km 64.5, La Finca, Villa Guerrero, Estado de México, México.Unidad de Biotecnología Medica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Avenida Normalistas 800, Col. Colinas de la Normal, 44270. Guadalajara, Jalisco, México.Unidad de Biotecnología Medica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Avenida Normalistas 800, Col. Colinas de la Normal, 44270. Guadalajara, Jalisco, México.Unidad de Biotecnología Medica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Avenida Normalistas 800, Col. Colinas de la Normal, 44270. Guadalajara, Jalisco, México.Unidad de Biotecnología Medica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Avenida Normalistas 800, Col. Colinas de la Normal, 44270. Guadalajara, Jalisco, México.Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial, antioxidant, among others. However, these properties in peel have been poorly explored. Aims: Evaluate the wound healing activity induced by an incision wound model using methanolic, hexanoic and chloroformic extracts from M. paradisiaca peel. Methods: Dehydrated M. paradisíaca peel was mixed with methanol, hexane, and chloroform. The presence of bioactive substances of the M. paradisiaca peel extracts was carried out by the Trease and Evans methods. Antioxidant capacity was evaluated by the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method. Acute toxicity was realized according to up and down OECD procedure in BALB/c mice. Wound healing activity was evaluated in male Wistar rats. Histological analyses of tissues were made by microscopy using staining methods of hematoxylin and eosin and Masson-trichrome. Results: Treated groups with methanolic and hexanoic extracts of M. paradisiaca peel showed better wound healing activity in comparison with the group treated with chloroformic extract, with an inhibition of DPPH radical bleaching of 89-90%. It may be due to the presence of alkaloids, tannins, saponins and phenols as principal constituents by conferring antioxidant capacity. The extract did not induce any toxicity. Conclusions: The findings showed the wound healing and antioxidant capacity of M. paradisiaca peel extract. It was observed that depending on the extraction solvent; there is a variation in the antioxidant capacity that also affects the effectiveness of the restoration of tissue, suggesting that the antioxidant capacity could play a major role in the process of wound healing.http://jppres.com/jppres/pdf/vol4/jppres16.124_4.5.165.pdfAntioxidant capacitybanana peelMusa paradisiacawound healing activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eduardo Padilla-Camberos José M. Flores-Fernández Alejandro A. Canales-Aguirre Carla P. Barragán-Álvarez Yanet Gutiérrez-Mercado Eugenia Lugo-Cervantes |
spellingShingle |
Eduardo Padilla-Camberos José M. Flores-Fernández Alejandro A. Canales-Aguirre Carla P. Barragán-Álvarez Yanet Gutiérrez-Mercado Eugenia Lugo-Cervantes Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts Journal of Pharmacy & Pharmacognosy Research Antioxidant capacity banana peel Musa paradisiaca wound healing activity |
author_facet |
Eduardo Padilla-Camberos José M. Flores-Fernández Alejandro A. Canales-Aguirre Carla P. Barragán-Álvarez Yanet Gutiérrez-Mercado Eugenia Lugo-Cervantes |
author_sort |
Eduardo Padilla-Camberos |
title |
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts |
title_short |
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts |
title_full |
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts |
title_fullStr |
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts |
title_full_unstemmed |
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts |
title_sort |
wound healing and antioxidant capacity of musa paradisiaca linn. peel extracts |
publisher |
Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) |
series |
Journal of Pharmacy & Pharmacognosy Research |
issn |
0719-4250 |
publishDate |
2016-10-01 |
description |
Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial, antioxidant, among others. However, these properties in peel have been poorly explored.
Aims: Evaluate the wound healing activity induced by an incision wound model using methanolic, hexanoic and chloroformic extracts from M. paradisiaca peel.
Methods: Dehydrated M. paradisíaca peel was mixed with methanol, hexane, and chloroform. The presence of bioactive substances of the M. paradisiaca peel extracts was carried out by the Trease and Evans methods. Antioxidant capacity was evaluated by the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method. Acute toxicity was realized according to up and down OECD procedure in BALB/c mice. Wound healing activity was evaluated in male Wistar rats. Histological analyses of tissues were made by microscopy using staining methods of hematoxylin and eosin and Masson-trichrome.
Results: Treated groups with methanolic and hexanoic extracts of M. paradisiaca peel showed better wound healing activity in comparison with the group treated with chloroformic extract, with an inhibition of DPPH radical bleaching of 89-90%. It may be due to the presence of alkaloids, tannins, saponins and phenols as principal constituents by conferring antioxidant capacity. The extract did not induce any toxicity.
Conclusions: The findings showed the wound healing and antioxidant capacity of M. paradisiaca peel extract. It was observed that depending on the extraction solvent; there is a variation in the antioxidant capacity that also affects the effectiveness of the restoration of tissue, suggesting that the antioxidant capacity could play a major role in the process of wound healing. |
topic |
Antioxidant capacity banana peel Musa paradisiaca wound healing activity |
url |
http://jppres.com/jppres/pdf/vol4/jppres16.124_4.5.165.pdf |
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