Lactate levels affect motor performance in MD 1
Myotonic Dystrophy type 1 (DM1) is a dominantly inherited disease comprehending multiple features. Fatigue and exhaustion during exercise often represent significant factors able to negatively influence their compliance to rehabilitation programs. Mitochondrial abnormalities and a significant increa...
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doaj-c68f3c1a86ff4aa2b3927077905eab232020-11-25T00:26:16ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602014-12-0124410.4081/ejtm.2014.47264071Lactate levels affect motor performance in MD 1Caterina Tramonti0Stefania Dalise1Federica Bertolucci2Bruno Rossi3Carmelo Chisari4Unit of Neurorehabilitation, Department of Neuroscience, University Hospital of PisaUnit of Neurorehabilitation, Department of Neuroscience, University Hospital of PisaUnit of Neurorehabilitation, Department of Neuroscience, University Hospital of PisaUnit of Neurorehabilitation, Department of Neuroscience, University Hospital of PisaUnit of Neurorehabilitation, Department of Neuroscience, University Hospital of PisaMyotonic Dystrophy type 1 (DM1) is a dominantly inherited disease comprehending multiple features. Fatigue and exhaustion during exercise often represent significant factors able to negatively influence their compliance to rehabilitation programs. Mitochondrial abnormalities and a significant increase in oxidative markers, previously reported, suggest the hypothesis of a mitochondrial functional impairment. The study aims at evaluating oxidative metabolism efficiency in 18 DM1 patients and in 15 healthy subjects, through analysis of lactate levels at rest and after an incremental exercise test. The exercise protocol consisted of a submaximal incremental exercise performed on an electronically calibrated treadmill, maintained in predominantly aerobic condition. Lactate levels were assessed at rest and at 5, 10 and 30 minutes after the end of the exercise. The results showed early exercise-related fatigue in DM1 patients, as they performed a mean number of 9 steps, while controls completed the whole exercise. Moreover, while resting values of lactate were comparable between the patients and the control group (p=0.69), after the exercise protocol, dystrophic subjects reached higher values of lactate, at any recovery time (p<0,05). These observations suggest an early activation of anaerobic metabolism, thus evidencing an alteration in oxidative metabolism of such dystrophic patients. As far as intense aerobic training could be performed in DM1 patients, in order to improve maximal muscle oxidative capacity and blood lactate removal ability, then, this safe and validate method could be used to evaluate muscle oxidative metabolism and provide an efficient help on rehabilitation programs to be prescribed in such patients.http://pagepressjournals.org/index.php/bam/article/view/4726Myotonic Dystrophy type 1Oxidative MetabolismAerobic TrainingIncremental exercise testLactate acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Caterina Tramonti Stefania Dalise Federica Bertolucci Bruno Rossi Carmelo Chisari |
spellingShingle |
Caterina Tramonti Stefania Dalise Federica Bertolucci Bruno Rossi Carmelo Chisari Lactate levels affect motor performance in MD 1 European Journal of Translational Myology Myotonic Dystrophy type 1 Oxidative Metabolism Aerobic Training Incremental exercise test Lactate acid |
author_facet |
Caterina Tramonti Stefania Dalise Federica Bertolucci Bruno Rossi Carmelo Chisari |
author_sort |
Caterina Tramonti |
title |
Lactate levels affect motor performance in MD 1 |
title_short |
Lactate levels affect motor performance in MD 1 |
title_full |
Lactate levels affect motor performance in MD 1 |
title_fullStr |
Lactate levels affect motor performance in MD 1 |
title_full_unstemmed |
Lactate levels affect motor performance in MD 1 |
title_sort |
lactate levels affect motor performance in md 1 |
publisher |
PAGEPress Publications |
series |
European Journal of Translational Myology |
issn |
2037-7452 2037-7460 |
publishDate |
2014-12-01 |
description |
Myotonic Dystrophy type 1 (DM1) is a dominantly inherited disease comprehending multiple features. Fatigue and exhaustion during exercise often represent significant factors able to negatively influence their compliance to rehabilitation programs. Mitochondrial abnormalities and a significant increase in oxidative markers, previously reported, suggest the hypothesis of a mitochondrial functional impairment. The study aims at evaluating oxidative metabolism efficiency in 18 DM1 patients and in 15 healthy subjects, through analysis of lactate levels at rest and after an incremental exercise test. The exercise protocol consisted of a submaximal incremental exercise performed on an electronically calibrated treadmill, maintained in predominantly aerobic condition. Lactate levels were assessed at rest and at 5, 10 and 30 minutes after the end of the exercise. The results showed early exercise-related fatigue in DM1 patients, as they performed a mean number of 9 steps, while controls completed the whole exercise. Moreover, while resting values of lactate were comparable between the patients and the control group (p=0.69), after the exercise protocol, dystrophic subjects reached higher values of lactate, at any recovery time (p<0,05). These observations suggest an early activation of anaerobic metabolism, thus evidencing an alteration in oxidative metabolism of such dystrophic patients. As far as intense aerobic training could be performed in DM1 patients, in order to improve maximal muscle oxidative capacity and blood lactate removal ability, then, this safe and validate method could be used to evaluate muscle oxidative metabolism and provide an efficient help on rehabilitation programs to be prescribed in such patients. |
topic |
Myotonic Dystrophy type 1 Oxidative Metabolism Aerobic Training Incremental exercise test Lactate acid |
url |
http://pagepressjournals.org/index.php/bam/article/view/4726 |
work_keys_str_mv |
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