FoxO1-mediated autophagy is required for NK cell development and innate immunity
Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11023 |
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Article |
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doaj-c697bebcc1d3445d9375a769a48af9642021-05-11T11:00:26ZengNature Publishing GroupNature Communications2041-17232016-03-017111510.1038/ncomms11023FoxO1-mediated autophagy is required for NK cell development and innate immunityShuo Wang0Pengyan Xia1Guanling Huang2Pingping Zhu3Jing Liu4Buqing Ye5Ying Du6Zusen Fan7CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesNatural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species.https://doi.org/10.1038/ncomms11023 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan |
| spellingShingle |
Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan FoxO1-mediated autophagy is required for NK cell development and innate immunity Nature Communications |
| author_facet |
Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan |
| author_sort |
Shuo Wang |
| title |
FoxO1-mediated autophagy is required for NK cell development and innate immunity |
| title_short |
FoxO1-mediated autophagy is required for NK cell development and innate immunity |
| title_full |
FoxO1-mediated autophagy is required for NK cell development and innate immunity |
| title_fullStr |
FoxO1-mediated autophagy is required for NK cell development and innate immunity |
| title_full_unstemmed |
FoxO1-mediated autophagy is required for NK cell development and innate immunity |
| title_sort |
foxo1-mediated autophagy is required for nk cell development and innate immunity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species. |
| url |
https://doi.org/10.1038/ncomms11023 |
| work_keys_str_mv |
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1721447232295665664 |