Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline in the regenerative capacity of ISCs upon aging b...

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Bibliographic Details
Main Authors: Kodandaramireddy Nalapareddy, Kalpana J. Nattamai, Rupali S. Kumar, Rebekah Karns, Kathryn A. Wikenheiser-Brokamp, Leesa L. Sampson, Maxime M. Mahe, Nambirajan Sundaram, Mary-Beth Yacyshyn, Bruce Yacyshyn, Michael A. Helmrath, Yi Zheng, Hartmut Geiger
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
aging
regeneration
intestinal stem cells
Wnt signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302541

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