Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain p...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nofer Institute of Occupational Medicine
2018-03-01
|
Series: | Medycyna Pracy |
Subjects: | |
Online Access: | http://www.journalssystem.com/medpr/Polimorfizm-genow-kodujacych-bialka-naprawy-DNA-a-zawodowe-i-srodowiskowe-narazenie,75879,0,2.html |
id |
doaj-c6b4225b634243b08251998b66882bdd |
---|---|
record_format |
Article |
spelling |
doaj-c6b4225b634243b08251998b66882bdd2020-11-24T22:50:46ZengNofer Institute of Occupational MedicineMedycyna Pracy0465-58932353-13392018-03-0169222523510.13075/mp.5893.0059575879Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticidesKarol Bukowski0Katarzyna Woźniak1Uniwersytet Łódzki / University of Lodz, Łódź, Poland (Wydział Biologii i Ochrony Środowiska, Katedra Genetyki Molekularnej / Faculty of Biology and Environmental Protection, Department of Molecular Genetics)Uniwersytet Łódzki / University of Lodz, Łódź, Poland (Wydział Biologii i Ochrony Środowiska, Katedra Genetyki Molekularnej / Faculty of Biology and Environmental Protection, Department of Molecular Genetics)Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals, such as lead, arsenic pesticides are considered to exhibit strong toxicity. There are many different polymorphisms in genes encoding DNA repair enzymes, which determine the speed and efficiency of DNA damage repair induced by these xenobiotics. In the case of lead, the influence of various polymorphisms, such as APE1 (apurinic/apyrimidinic endonuclease 1) (rs1130409), hOGG1 (human 8-oxoguanine glycosylase) (rs1052133), XRCC1 (X-ray repair cross-complementing protein group 1) (rs25487), XRCC1 (rs1799782) and XRCC3 (X-ray repair cross-complementing protein group 3) (rs861539) were described. For arsenic polymorphisms, such as ERCC2 (excision repair cross-complementing) (rs13181), XRCC3 (rs861539), APE1 (rs1130409) and hOGG1 (rs1052133) were examined. As to pesticides, separate and combined effects of polymorphisms in genes encoding DNA repair enzymes, such as XRCC1 (rs1799782), hOGG1 (rs1052133), XRCC4 (X-ray repair cross-complementing protein group 4) (rs28360135) and the gene encoding the detoxification enzyme PON1 paraoxonase (rs662) were reported. Med Pr 2018;69(2):225–235http://www.journalssystem.com/medpr/Polimorfizm-genow-kodujacych-bialka-naprawy-DNA-a-zawodowe-i-srodowiskowe-narazenie,75879,0,2.htmlgenetic polymorphismarsenicPesticidesleadDNA damageDNA repair genes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karol Bukowski Katarzyna Woźniak |
spellingShingle |
Karol Bukowski Katarzyna Woźniak Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides Medycyna Pracy genetic polymorphism arsenic Pesticides lead DNA damage DNA repair genes |
author_facet |
Karol Bukowski Katarzyna Woźniak |
author_sort |
Karol Bukowski |
title |
Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
title_short |
Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
title_full |
Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
title_fullStr |
Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
title_full_unstemmed |
Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
title_sort |
polymorphism of genes encoding proteins of dna repair
vs. occupational and environmental exposure to lead, arsenic and pesticides |
publisher |
Nofer Institute of Occupational Medicine |
series |
Medycyna Pracy |
issn |
0465-5893 2353-1339 |
publishDate |
2018-03-01 |
description |
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher
than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of
variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated
with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals,
such as lead, arsenic pesticides are considered to exhibit strong toxicity. There are many different polymorphisms in genes
encoding DNA repair enzymes, which determine the speed and efficiency of DNA damage repair induced by these xenobiotics.
In the case of lead, the influence of various polymorphisms, such as APE1 (apurinic/apyrimidinic endonuclease 1) (rs1130409),
hOGG1 (human 8-oxoguanine glycosylase) (rs1052133), XRCC1 (X-ray repair cross-complementing protein group 1) (rs25487),
XRCC1 (rs1799782) and XRCC3 (X-ray repair cross-complementing protein group 3) (rs861539) were described. For arsenic polymorphisms,
such as ERCC2 (excision repair cross-complementing) (rs13181), XRCC3 (rs861539), APE1 (rs1130409) and hOGG1
(rs1052133) were examined. As to pesticides, separate and combined effects of polymorphisms in genes encoding DNA repair enzymes,
such as XRCC1 (rs1799782), hOGG1 (rs1052133), XRCC4 (X-ray repair cross-complementing protein group 4) (rs28360135)
and the gene encoding the detoxification enzyme PON1 paraoxonase (rs662) were reported. Med Pr 2018;69(2):225–235 |
topic |
genetic polymorphism arsenic Pesticides lead DNA damage DNA repair genes |
url |
http://www.journalssystem.com/medpr/Polimorfizm-genow-kodujacych-bialka-naprawy-DNA-a-zawodowe-i-srodowiskowe-narazenie,75879,0,2.html |
work_keys_str_mv |
AT karolbukowski polymorphismofgenesencodingproteinsofdnarepairvsoccupationalandenvironmentalexposuretoleadarsenicandpesticides AT katarzynawozniak polymorphismofgenesencodingproteinsofdnarepairvsoccupationalandenvironmentalexposuretoleadarsenicandpesticides |
_version_ |
1725671502672560128 |