Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization
Abstract Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared...
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doaj-c6b66bbd55104f199353f38e01ebb7352021-02-07T12:25:14ZengBMCCancer Nanotechnology1868-69581868-69662021-02-0112111910.1186/s12645-021-00075-xExcretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitizationJossana A. Damasco0Tymish Y. Ohulchanskyy1Supriya Mahajan2Guanying Chen3Ajay Singh4Hilliard L. Kutscher5Haoyuan Huang6Steven G. Turowski7Joseph A. Spernyak8Anurag K. Singh9Jonathan F. Lovell10Mukund Seshadri11Paras N. Prasad12Department of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkDepartment of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkDepartment of Medicine, Division of Allergy, Immunology and Rheumatology, University At Buffalo, The State University of New YorkDepartment of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkDepartment of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkDepartment of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University At Buffalo, The State University of New YorkTranslational Imaging Shared Resource, Roswell Park Comprehensive Cancer CenterTranslational Imaging Shared Resource, Roswell Park Comprehensive Cancer CenterDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer CenterDepartment of Biomedical Engineering, University At Buffalo, The State University of New YorkTranslational Imaging Shared Resource, Roswell Park Comprehensive Cancer CenterDepartment of Chemistry and Institute for Lasers, Photonics and Biophotonics, University At Buffalo, The State University of New YorkAbstract Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided that the nanoparticles are taken up intracellularly. Results Our ultrasmall β-NaGdF4:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohexol. A 2 Gy dose of X-ray induced ~ 20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~ 60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS. Conclusion These biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications.https://doi.org/10.1186/s12645-021-00075-xGadolinium nanoparticlesRadiosensitizerTheranosticsMR/CT imaging probesGlioblastoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jossana A. Damasco Tymish Y. Ohulchanskyy Supriya Mahajan Guanying Chen Ajay Singh Hilliard L. Kutscher Haoyuan Huang Steven G. Turowski Joseph A. Spernyak Anurag K. Singh Jonathan F. Lovell Mukund Seshadri Paras N. Prasad |
spellingShingle |
Jossana A. Damasco Tymish Y. Ohulchanskyy Supriya Mahajan Guanying Chen Ajay Singh Hilliard L. Kutscher Haoyuan Huang Steven G. Turowski Joseph A. Spernyak Anurag K. Singh Jonathan F. Lovell Mukund Seshadri Paras N. Prasad Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization Cancer Nanotechnology Gadolinium nanoparticles Radiosensitizer Theranostics MR/CT imaging probes Glioblastoma |
author_facet |
Jossana A. Damasco Tymish Y. Ohulchanskyy Supriya Mahajan Guanying Chen Ajay Singh Hilliard L. Kutscher Haoyuan Huang Steven G. Turowski Joseph A. Spernyak Anurag K. Singh Jonathan F. Lovell Mukund Seshadri Paras N. Prasad |
author_sort |
Jossana A. Damasco |
title |
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization |
title_short |
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization |
title_full |
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization |
title_fullStr |
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization |
title_full_unstemmed |
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization |
title_sort |
excretable, ultrasmall hexagonal nagdf4:yb50% nanoparticles for bimodal imaging and radiosensitization |
publisher |
BMC |
series |
Cancer Nanotechnology |
issn |
1868-6958 1868-6966 |
publishDate |
2021-02-01 |
description |
Abstract Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided that the nanoparticles are taken up intracellularly. Results Our ultrasmall β-NaGdF4:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohexol. A 2 Gy dose of X-ray induced ~ 20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~ 60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS. Conclusion These biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. |
topic |
Gadolinium nanoparticles Radiosensitizer Theranostics MR/CT imaging probes Glioblastoma |
url |
https://doi.org/10.1186/s12645-021-00075-x |
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