Stability and efficacy of sunscreens containing inorganic filters and quercetin
Exposure to the sun can have health benefits, however, excess exposure can cause skin damage, such as skin cancer. Photoprotection can be used as a preventive method against the harmful effects of the ultraviolet (UV) radiation and Brazilian biodiversity is a fertile field for research in this area....
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ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde
2013-06-01
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Series: | Journal Biomedical and Biopharmaceutical Research (BBR) |
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doaj-c6b9a3da8d754174938f4dfcb91f41312020-11-24T23:56:14ZengALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da SaúdeJournal Biomedical and Biopharmaceutical Research (BBR) 2182-23602182-23792013-06-011019110010.19277/bbr.10.1.55Stability and efficacy of sunscreens containing inorganic filters and quercetinDeborah de Oliveira Nishikawa0Daniela D'Almeida Peres1Daniela D'Almeida Peres2Camila Areias de Oliveira3Vânia Rodrigues Leite e Silva4Telma Mary Kaneko5Maria Valéria Robles Velasco6André Rolim Baby7School of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilSchool of Pharmaceutical Sciences, University of São Paulo. São Paulo, SP, BrazilExposure to the sun can have health benefits, however, excess exposure can cause skin damage, such as skin cancer. Photoprotection can be used as a preventive method against the harmful effects of the ultraviolet (UV) radiation and Brazilian biodiversity is a fertile field for research in this area. Therefore, the aim of this study was the development of sunscreens containing quercetin (bioactive compound) and inorganic filters (titanium dioxide and zinc oxide) with further characterization of the formulae and evaluation of stability. Formulations containing the bioactive compound, isolated or in association with the inorganic filters, presented: pH values biocompatible with the skin; apparent viscosity between 10550 and 23600 cP; sun protection factor (SPF) between 2.1 and 22.5; and broad spectrum protection, with critical wavelengths above 379 nm. It was found that the association of quercetin with inorganic filters was not adequate due to the negative interactions that occurred between the bioactive compound and the metals, which were only identified during the stability study. However, considering the in vitro estimated efficacy of the isolated flavonoid, its use can still be explored as an alternative substitute to classic UVfilters.http://www.alies.pt/BBR%20Editions/Vol-10-1-2013/Article9_10n1.pdfPhotoprotectionQuercetinStabilityTitanium dioxideZinc oxide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Deborah de Oliveira Nishikawa Daniela D'Almeida Peres Daniela D'Almeida Peres Camila Areias de Oliveira Vânia Rodrigues Leite e Silva Telma Mary Kaneko Maria Valéria Robles Velasco André Rolim Baby |
spellingShingle |
Deborah de Oliveira Nishikawa Daniela D'Almeida Peres Daniela D'Almeida Peres Camila Areias de Oliveira Vânia Rodrigues Leite e Silva Telma Mary Kaneko Maria Valéria Robles Velasco André Rolim Baby Stability and efficacy of sunscreens containing inorganic filters and quercetin Journal Biomedical and Biopharmaceutical Research (BBR) Photoprotection Quercetin Stability Titanium dioxide Zinc oxide |
author_facet |
Deborah de Oliveira Nishikawa Daniela D'Almeida Peres Daniela D'Almeida Peres Camila Areias de Oliveira Vânia Rodrigues Leite e Silva Telma Mary Kaneko Maria Valéria Robles Velasco André Rolim Baby |
author_sort |
Deborah de Oliveira Nishikawa |
title |
Stability and efficacy of sunscreens containing inorganic filters and quercetin |
title_short |
Stability and efficacy of sunscreens containing inorganic filters and quercetin |
title_full |
Stability and efficacy of sunscreens containing inorganic filters and quercetin |
title_fullStr |
Stability and efficacy of sunscreens containing inorganic filters and quercetin |
title_full_unstemmed |
Stability and efficacy of sunscreens containing inorganic filters and quercetin |
title_sort |
stability and efficacy of sunscreens containing inorganic filters and quercetin |
publisher |
ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde |
series |
Journal Biomedical and Biopharmaceutical Research (BBR) |
issn |
2182-2360 2182-2379 |
publishDate |
2013-06-01 |
description |
Exposure to the sun can have health benefits, however, excess exposure can cause skin damage, such as skin cancer. Photoprotection can be used as a preventive method against the harmful effects of the ultraviolet (UV) radiation and Brazilian biodiversity is a fertile field for research in this area. Therefore, the aim of this study was the development of sunscreens containing quercetin (bioactive compound) and inorganic filters (titanium dioxide and zinc oxide) with further characterization of the formulae and evaluation of stability. Formulations containing the bioactive compound, isolated or in association with the inorganic filters, presented: pH values biocompatible with the skin; apparent viscosity between 10550 and 23600 cP; sun protection factor (SPF) between 2.1 and 22.5; and broad spectrum protection, with critical wavelengths above 379 nm. It was found that the association of quercetin with inorganic filters was not adequate due to the negative interactions that occurred between the bioactive compound and the metals, which were only identified during the stability study. However, considering the in vitro estimated efficacy of the isolated flavonoid, its use can still be explored as an alternative substitute to classic UVfilters. |
topic |
Photoprotection Quercetin Stability Titanium dioxide Zinc oxide |
url |
http://www.alies.pt/BBR%20Editions/Vol-10-1-2013/Article9_10n1.pdf |
work_keys_str_mv |
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