Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this regio...
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doaj-c6c0c2bb5b144690b473cf07f4bb69c82020-11-25T02:06:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017288010.1371/journal.pone.0172880Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.Esteban J ParraAndrew MazurekChristopher R GignouxAlexandra SockellMichael AgostinoAndrew P MorrisLauren E PettyCraig L HanisNancy J CoxAdan Valladares-SalgadoJennifer E BelowMiguel CruzWe carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.http://europepmc.org/articles/PMC5330487?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esteban J Parra Andrew Mazurek Christopher R Gignoux Alexandra Sockell Michael Agostino Andrew P Morris Lauren E Petty Craig L Hanis Nancy J Cox Adan Valladares-Salgado Jennifer E Below Miguel Cruz |
spellingShingle |
Esteban J Parra Andrew Mazurek Christopher R Gignoux Alexandra Sockell Michael Agostino Andrew P Morris Lauren E Petty Craig L Hanis Nancy J Cox Adan Valladares-Salgado Jennifer E Below Miguel Cruz Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. PLoS ONE |
author_facet |
Esteban J Parra Andrew Mazurek Christopher R Gignoux Alexandra Sockell Michael Agostino Andrew P Morris Lauren E Petty Craig L Hanis Nancy J Cox Adan Valladares-Salgado Jennifer E Below Miguel Cruz |
author_sort |
Esteban J Parra |
title |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. |
title_short |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. |
title_full |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. |
title_fullStr |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. |
title_full_unstemmed |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. |
title_sort |
admixture mapping in two mexican samples identifies significant associations of locus ancestry with triglyceride levels in the bud13/znf259/apoa5 region and fine mapping points to rs964184 as the main driver of the association signal. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene. |
url |
http://europepmc.org/articles/PMC5330487?pdf=render |
work_keys_str_mv |
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