Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this regio...
Main Authors: | Esteban J Parra, Andrew Mazurek, Christopher R Gignoux, Alexandra Sockell, Michael Agostino, Andrew P Morris, Lauren E Petty, Craig L Hanis, Nancy J Cox, Adan Valladares-Salgado, Jennifer E Below, Miguel Cruz |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5330487?pdf=render |
Similar Items
-
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations
by: Ling Qiu, et al.
Published: (2018-05-01) -
Comparison of measures of marker informativeness for ancestry and admixture mapping
by: Ding Lili, et al.
Published: (2011-12-01) -
Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.
by: Qianxi Fu, et al.
Published: (2015-01-01) -
Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.
by: Calvin Chi, et al.
Published: (2019-01-01) -
Ancestry and admixture rates: the matter of evolution in admixture study
by: G. Gourjon, et al.
Published: (2012-11-01)