Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose

Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose

Aims/hypothesisRecurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and awareness of hypoglycaemia. Little is known about the i...

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Bibliographic Details
Main Authors: Paul G. Weightman Potter, Sam J. Washer, Aaron R. Jeffries, Janet E. Holley, Nick J. Gutowski, Emma L. Dempster, Craig Beall
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
recurrent low glucose
unfolded protein response
ER stress
human primary astrocytes
transcriptome (RNA-seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.671724/full

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