Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes.

Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes.

VEGFA is an angiogenic factor secreted by tumors, in particular those with VEGFA amplification, as well as by macrophages and lymphocytes in the tumor microenvironment. Here we sought to define the presence of M1/M2 macrophages, PD-1-positive lymphocytes and PD-L1 tumoral and stromal expression in c...

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Main Authors: Katharina Burmeister, Luca Quagliata, Mariacarla Andreozzi, Serenella Eppenberger-Castori, Matthias S Matter, Valeria Perrina, Rainer Grobholz, Wolfram Jochum, Daniel Horber, Peter Moosmann, Frank Lehmann, Dieter Köberle, Charlotte K Y Ng, Salvatore Piscuoglio, Luigi Tornillo, Luigi M Terracciano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5389821?pdf=render

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