Synthesis of 10-<i>O</i>-aryl-substituted berberine derivatives by Chan–Evans–Lam coupling and investigation of their DNA-binding properties

Synthesis of 10-<i>O</i>-aryl-substituted berberine derivatives by Chan–Evans–Lam coupling and investigation of their DNA-binding properties

Eleven novel 10-<i>O</i>-aryl-substituted berberrubine and berberine derivatives were synthesized by the Cu<sup>2+</sup>-catalyzed Chan–Evans–Lam coupling of berberrubine with arylboronic acids and subsequent 9-<i>O</i>-methylation. The reaction is likely introduc...

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Bibliographic Details
Main Authors: Peter Jonas Wickhorst, Mathilda Blachnik, Denisa Lagumdzija, Heiko Ihmels
Format: Article
Language:English
Published: Beilstein-Institut 2021-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
berberine alkaloids
cu-mediated coupling reactions
dna recognition
nucleic acids
quadruplex dna
Online Access:https://doi.org/10.3762/bjoc.17.81

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