Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease.
Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. Both prohibitin over- and under-expression have been implicated in various...
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2013-01-01
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doaj-c6e631ec4e8041dc8aab7bd3956d36c32020-11-25T01:20:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7718710.1371/journal.pone.0077187Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease.Tian-Biao ZhouYuan-Han QinFeng-Ying LeiWei-Fang HuangGregor P C DrummenProhibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. Both prohibitin over- and under-expression have been implicated in various diseases and cell types. We recently demonstrated that prohibitin down-regulation results in increased renal interstitial fibrosis (RIF). Here we investigated the role of oxidative stress and prohibitin expression in RIF in unilateral ureteral obstructed rats. Lentivirus-based delivery vectors were used to knockdown or over-express prohibitin. Our results show that increased prohibitin expression was negatively correlated with the RIF index, reactive oxygen species, malon dialdehyde, transforming growth factor β1, collagen IV, fibronectin, and cell apoptosis index. In conclusion, we postulate that prohibitin acts as a positive regulator of mechanisms that counteract oxidative stress and extracellular matrix accumulation and therefore has an antioxidative effect.http://europepmc.org/articles/PMC3808389?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian-Biao Zhou Yuan-Han Qin Feng-Ying Lei Wei-Fang Huang Gregor P C Drummen |
spellingShingle |
Tian-Biao Zhou Yuan-Han Qin Feng-Ying Lei Wei-Fang Huang Gregor P C Drummen Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. PLoS ONE |
author_facet |
Tian-Biao Zhou Yuan-Han Qin Feng-Ying Lei Wei-Fang Huang Gregor P C Drummen |
author_sort |
Tian-Biao Zhou |
title |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
title_short |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
title_full |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
title_fullStr |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
title_full_unstemmed |
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
title_sort |
prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. Both prohibitin over- and under-expression have been implicated in various diseases and cell types. We recently demonstrated that prohibitin down-regulation results in increased renal interstitial fibrosis (RIF). Here we investigated the role of oxidative stress and prohibitin expression in RIF in unilateral ureteral obstructed rats. Lentivirus-based delivery vectors were used to knockdown or over-express prohibitin. Our results show that increased prohibitin expression was negatively correlated with the RIF index, reactive oxygen species, malon dialdehyde, transforming growth factor β1, collagen IV, fibronectin, and cell apoptosis index. In conclusion, we postulate that prohibitin acts as a positive regulator of mechanisms that counteract oxidative stress and extracellular matrix accumulation and therefore has an antioxidative effect. |
url |
http://europepmc.org/articles/PMC3808389?pdf=render |
work_keys_str_mv |
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