Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities

Six thiazolyl-pyrazoline derivatives were synthesized starting from corresponding chalcone compounds for their antioxidant capacity and antiurease inhibitory activities. In addition to the conventional method, ultrasonic sonication and microwave irradiation methods which are environmental methods w...

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Main Author:	Arif MERMER
Format:	Article
Language:	English
Published:	Turkish Chemical Society 2020-02-01
Series:	Journal of the Turkish Chemical Society, Section A: Chemistry
Subjects:	thiazole microwave irradiation ultrasound sonication biological activity
Online Access:	https://dergipark.org.tr/en/pub/jotcsa/issue/49279/563286

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spelling	doaj-c6f34400d66f4bb1a5b709d93ee5bd542020-11-25T02:22:49ZengTurkish Chemical SocietyJournal of the Turkish Chemical Society, Section A: Chemistry2149-01202020-02-01712536https://doi.org/10.18596/jotcsa.563286Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activitiesArif MERMER0https://orcid.org/0000-0002-4789-7180Karadeniz Technical University Six thiazolyl-pyrazoline derivatives were synthesized starting from corresponding chalcone compounds for their antioxidant capacity and antiurease inhibitory activities. In addition to the conventional method, ultrasonic sonication and microwave irradiation methods which are environmental methods were used in the synthesis stage. Compound 2-(5-(3-bromophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenyl thiazole (5a) exhibited the most potent antiurease activity with IC50 of 2,28±0,02, which was comparable to the positive control. https://dergipark.org.tr/en/pub/jotcsa/issue/49279/563286thiazolemicrowave irradiationultrasound sonicationbiological activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Arif MERMER
spellingShingle	Arif MERMER Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities Journal of the Turkish Chemical Society, Section A: Chemistry thiazole microwave irradiation ultrasound sonication biological activity
author_facet	Arif MERMER
author_sort	Arif MERMER
title	Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
title_short	Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
title_full	Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
title_fullStr	Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
title_full_unstemmed	Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
title_sort	microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
publisher	Turkish Chemical Society
series	Journal of the Turkish Chemical Society, Section A: Chemistry
issn	2149-0120
publishDate	2020-02-01
description	Six thiazolyl-pyrazoline derivatives were synthesized starting from corresponding chalcone compounds for their antioxidant capacity and antiurease inhibitory activities. In addition to the conventional method, ultrasonic sonication and microwave irradiation methods which are environmental methods were used in the synthesis stage. Compound 2-(5-(3-bromophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenyl thiazole (5a) exhibited the most potent antiurease activity with IC50 of 2,28±0,02, which was comparable to the positive control.
topic	thiazole microwave irradiation ultrasound sonication biological activity
url	https://dergipark.org.tr/en/pub/jotcsa/issue/49279/563286
work_keys_str_mv	AT arifmermer microwaveandultrasoundpromotedgreenersynthesisofthiazolylpyrazolinederivativesandinvestigationoftheirbiologicalactivities
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Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities

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