IDENTIFICATION OF POLYMORPHOUS VARIANTS OF GENES REGULATING CELLULAR CYCLE IN CASE OF LUNG CANCER

IDENTIFICATION OF POLYMORPHOUS VARIANTS OF GENES REGULATING CELLULAR CYCLE IN CASE OF LUNG CANCER

The study investigated the distribution of polymorphous variants of genes regulating cellular cycle – p53 G215C, Bax G248A and Bcl-2 C938A in lung cancer patients and healthy donors with the purpose of obtaining new fundamental knowledge on the role of above polymorphisms in the lung cancer developm...

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Bibliographic Details
Main Authors: A. I. Dmitrieva, V. A. Serebryakova, I. A. Kuznetsova, S. S. Rakitin, L. A. Kudyakov, V. V. Novitskiy
Format: Article
Language:Russian
Published: NEW TERRA Publishing House 2015-10-01
Series:Tuberkulez i Bolezni Lëgkih
Subjects:
p53
bax
bcl-2
polymorphism
genes regulators of cellular circle
lung cancer
Online Access:https://www.tibl-journal.com/jour/article/view/807
Description
Summary:The study investigated the distribution of polymorphous variants of genes regulating cellular cycle – p53 G215C, Bax G248A and Bcl-2 C938A in lung cancer patients and healthy donors with the purpose of obtaining new fundamental knowledge on the role of above polymorphisms in the lung cancer development. The statistically significant di|erences were found out in the distribution of polymorphous variants of genes regulating cellular cycle in the compared groups; relative risks of cancer development were calculated for those carrying of polymorphous variants of genes of p53 G215C, Bax G248A and Bcl-2 C938A.
ISSN:2075-1230
2542-1506

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