High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites...

Full description

Bibliographic Details
Main Authors:	Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Simon M. G. Braun, Nicole Francis, Rabih Murr
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23630-x

id	doaj-c700bba4738648ac97b97852cfa493cc
record_format	Article
spelling	doaj-c700bba4738648ac97b97852cfa493cc2021-06-13T11:17:11ZengNature Publishing GroupNature Communications2041-17232021-06-0112111810.1038/s41467-021-23630-xHigh throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sitesLudovica Vanzan0Hadrien Soldati1Victor Ythier2Santosh Anand3Simon M. G. Braun4Nicole Francis5Rabih Murr6Department of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolInstitut de Recherches Cliniques de Montréal (IRCM) and Département de Biochimie et Médecine Moléculaire, Université de MontréalDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolThe functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.https://doi.org/10.1038/s41467-021-23630-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr
spellingShingle	Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites Nature Communications
author_facet	Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr
author_sort	Ludovica Vanzan
title	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_short	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_full	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_fullStr	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_full_unstemmed	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_sort	high throughput screening identifies sox2 as a super pioneer factor that inhibits dna methylation maintenance at its binding sites
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.
url	https://doi.org/10.1038/s41467-021-23630-x
work_keys_str_mv	AT ludovicavanzan highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT hadriensoldati highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT victorythier highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT santoshanand highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT simonmgbraun highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT nicolefrancis highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites AT rabihmurr highthroughputscreeningidentifiessox2asasuperpioneerfactorthatinhibitsdnamethylationmaintenanceatitsbindingsites
_version_	1721380061358063616

High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

Similar Items