High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites...
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2021-06-01
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Online Access: | https://doi.org/10.1038/s41467-021-23630-x |
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doaj-c700bba4738648ac97b97852cfa493cc2021-06-13T11:17:11ZengNature Publishing GroupNature Communications2041-17232021-06-0112111810.1038/s41467-021-23630-xHigh throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sitesLudovica Vanzan0Hadrien Soldati1Victor Ythier2Santosh Anand3Simon M. G. Braun4Nicole Francis5Rabih Murr6Department of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolInstitut de Recherches Cliniques de Montréal (IRCM) and Département de Biochimie et Médecine Moléculaire, Université de MontréalDepartment of Genetic Medicine and Development, University of Geneva Medical SchoolThe functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.https://doi.org/10.1038/s41467-021-23630-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr |
spellingShingle |
Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites Nature Communications |
author_facet |
Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr |
author_sort |
Ludovica Vanzan |
title |
High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites |
title_short |
High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites |
title_full |
High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites |
title_fullStr |
High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites |
title_full_unstemmed |
High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites |
title_sort |
high throughput screening identifies sox2 as a super pioneer factor that inhibits dna methylation maintenance at its binding sites |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-06-01 |
description |
The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation. |
url |
https://doi.org/10.1038/s41467-021-23630-x |
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