Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats.

• Main Authors: Priya Saxena, Dharamveer Panjwani
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Journal of Acute Disease
• Subjects: Ananas comosus; Isoproterenol; Cardiotoxicity; Myocardial infarction
• Online Access: http://www.sciencedirect.com/science/article/pii/S2221618914600512

Objectives: To evaluate the cardioprotective effects of hydro alcoholic extract of Ananas comosus (A. comosus) (HEAC), on Isoproterenol (ISO) induced myocardial infarction in Albino Wistar rats. Methods: Myocardial infarction was induced by Isoproterenol (85 mg/kg, s.c.) for two consecutive days at an interval of 24 h. Rats were pretreated with HEAC (200–400 mg/kg/day, oral) for a period of 30 days and Isoproterenol (ISO) was injected on 31st and 32nd day and after 24 h blood was collected through retro-orbital plexus for the estimation of biochemical parameters and histopathological studies were also performed. Results: In the present study, ISO administration significantly elevated the cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it decreases high density lipoprotein and total protein in plasma and administration of HEAC decreases the level of cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it increases high density lipoprotein and total protein levels. Pretreatment with the HEAC protected the cardiotoxicity induced by Isoproterenol. The histopathological findings of the ISO-induced myocardium showed infracted zone with inflammatory cells, lipid droplets, myocardial necrosis and vacuolization of myofibrils which were reduced by the pretreatment of HEAC. Conclusion: It can be concluded that HEAC possess cardioprotective activity against Isoproterenol induced myocardial infarction in rats.