High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

Abstract To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward their mass production. Perfused suspension culture (3D)...

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Bibliographic Details
Main Authors:	Felix Manstein, Kevin Ullmann, Christina Kropp, Caroline Halloin, Wiebke Triebert, Annika Franke, Clara‐Milena Farr, Anais Sahabian, Alexandra Haase, Yannik Breitkreuz, Michael Peitz, Oliver Brüstle, Stefan Kalies, Ulrich Martin, Ruth Olmer, Robert Zweigerdt
Format:	Article
Language:	English
Published:	Wiley 2021-07-01
Series:	Stem Cells Translational Medicine
Subjects:	high density culture human pluripotent stem cells in silico process modeling process scale‐up stirred tank bioreactor suspension culture
Online Access:	https://doi.org/10.1002/sctm.20-0453

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