The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

Abstract Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides wer...

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Main Authors: Pei-Feng Zhu, Zhi Dai, Bei Wang, Xin Wei, Hao-Fei Yu, Zi-Ru Yan, Xu-Dong Zhao, Ya-Ping Liu, Xiao-Dong Luo
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:Natural Products and Bioprospecting
Subjects:
Lycium barbarum
Phenolic amides
Anticancer activities
Glioma stem cell
Online Access:http://link.springer.com/article/10.1007/s13659-017-0134-x
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spelling doaj-c712c39577894072ab9e4bd456f972622020-11-24T22:13:29ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092017-06-017642143110.1007/s13659-017-0134-xThe Anticancer Activities Phenolic Amides from the Stem of Lycium barbarumPei-Feng Zhu0Zhi Dai1Bei Wang2Xin Wei3Hao-Fei Yu4Zi-Ru Yan5Xu-Dong Zhao6Ya-Ping Liu7Xiao-Dong Luo8State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of ZoologyState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-017-0134-xLycium barbarumPhenolic amidesAnticancer activitiesGlioma stem cell
collection DOAJ
language English
format Article
sources DOAJ
author Pei-Feng Zhu
Zhi Dai
Bei Wang
Xin Wei
Hao-Fei Yu
Zi-Ru Yan
Xu-Dong Zhao
Ya-Ping Liu
Xiao-Dong Luo
spellingShingle Pei-Feng Zhu
Zhi Dai
Bei Wang
Xin Wei
Hao-Fei Yu
Zi-Ru Yan
Xu-Dong Zhao
Ya-Ping Liu
Xiao-Dong Luo
The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
Natural Products and Bioprospecting
Lycium barbarum
Phenolic amides
Anticancer activities
Glioma stem cell
author_facet Pei-Feng Zhu
Zhi Dai
Bei Wang
Xin Wei
Hao-Fei Yu
Zi-Ru Yan
Xu-Dong Zhao
Ya-Ping Liu
Xiao-Dong Luo
author_sort Pei-Feng Zhu
title The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_short The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_full The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_fullStr The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_full_unstemmed The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_sort anticancer activities phenolic amides from the stem of lycium barbarum
publisher SpringerOpen
series Natural Products and Bioprospecting
issn 2192-2195
2192-2209
publishDate 2017-06-01
description Abstract Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. Graphical Abstract
topic Lycium barbarum
Phenolic amides
Anticancer activities
Glioma stem cell
url http://link.springer.com/article/10.1007/s13659-017-0134-x
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