Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
Series: | Dental Research Journal |
Subjects: | |
Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=110;epage=116;aulast=Hormozi |
id |
doaj-c713ce00efd34162850debf09ac1920c |
---|---|
record_format |
Article |
spelling |
doaj-c713ce00efd34162850debf09ac1920c2020-11-25T01:23:17ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552016-01-0113211011610.4103/1735-3327.178195Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastomaElham HormoziVahid Nourollahi FardMohammad Ali NaseriNima Haghighat JahromiForooz KeshaniBackground: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular cysts. CD10 antigen is a cell surface metalloendopeptidase, which inactivates various peptides that are physiologically active. Studies have shown that increase in the expression of CD10 in the stromal cells helps the progression of the tumor. Ameloblastoma (AB) is a local invasive tumor and given the role of supporting connective tissue stroma in the aggression and progression. The aim of the present study was to comparatively evaluate the expression of CD10 in the connective tissue stroma of AB and OKC as a KCOT. Materials and Methods: In this retrospective, cross-sectional study, 14 paraffin blocks of KCOT and 9 of AB (7 multicystic and 2 unicystic) were evaluated with CD10 immunohistochemical expression in the connective tissue stroma of AB and the connective tissue wall of KCOT. The data were analyzed with Fisher′s exact test (P < 0.05). Results: In 8 samples of 9 AB and in 13 samples of 14 KOT lesions, expression of CD10 was shown. Fisher′s exact test did not reveal any significant differences between these two lesions in the expression of CD10 (P = 0.64). Conclusion: The results of this study propose that high expression rate of CD10 might be one of the reasons for the aggressive behavior of AB and high recurrence rate of OKC and reinforce the classification of OKC as an odontogenic tumor.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=110;epage=116;aulast=HormoziAmeloblastomaCD10keratocysticodontogenic tumorodontogenic keratocyst |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elham Hormozi Vahid Nourollahi Fard Mohammad Ali Naseri Nima Haghighat Jahromi Forooz Keshani |
spellingShingle |
Elham Hormozi Vahid Nourollahi Fard Mohammad Ali Naseri Nima Haghighat Jahromi Forooz Keshani Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma Dental Research Journal Ameloblastoma CD10 keratocystic odontogenic tumor odontogenic keratocyst |
author_facet |
Elham Hormozi Vahid Nourollahi Fard Mohammad Ali Naseri Nima Haghighat Jahromi Forooz Keshani |
author_sort |
Elham Hormozi |
title |
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma |
title_short |
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma |
title_full |
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma |
title_fullStr |
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma |
title_full_unstemmed |
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma |
title_sort |
comparison of immunohistochemical expression of cd10 in keratocystic odontogenic tumor and ameloblastoma |
publisher |
Wolters Kluwer Medknow Publications |
series |
Dental Research Journal |
issn |
1735-3327 2008-0255 |
publishDate |
2016-01-01 |
description |
Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular cysts. CD10 antigen is a cell surface metalloendopeptidase, which inactivates various peptides that are physiologically active. Studies have shown that increase in the expression of CD10 in the stromal cells helps the progression of the tumor. Ameloblastoma (AB) is a local invasive tumor and given the role of supporting connective tissue stroma in the aggression and progression. The aim of the present study was to comparatively evaluate the expression of CD10 in the connective tissue stroma of AB and OKC as a KCOT.
Materials and Methods: In this retrospective, cross-sectional study, 14 paraffin blocks of KCOT and 9 of AB (7 multicystic and 2 unicystic) were evaluated with CD10 immunohistochemical expression in the connective tissue stroma of AB and the connective tissue wall of KCOT. The data were analyzed with Fisher′s exact test (P < 0.05).
Results: In 8 samples of 9 AB and in 13 samples of 14 KOT lesions, expression of CD10 was shown. Fisher′s exact test did not reveal any significant differences between these two lesions in the expression of CD10 (P = 0.64).
Conclusion: The results of this study propose that high expression rate of CD10 might be one of the reasons for the aggressive behavior of AB and high recurrence rate of OKC and reinforce the classification of OKC as an odontogenic tumor. |
topic |
Ameloblastoma CD10 keratocystic odontogenic tumor odontogenic keratocyst |
url |
http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=110;epage=116;aulast=Hormozi |
work_keys_str_mv |
AT elhamhormozi comparisonofimmunohistochemicalexpressionofcd10inkeratocysticodontogenictumorandameloblastoma AT vahidnourollahifard comparisonofimmunohistochemicalexpressionofcd10inkeratocysticodontogenictumorandameloblastoma AT mohammadalinaseri comparisonofimmunohistochemicalexpressionofcd10inkeratocysticodontogenictumorandameloblastoma AT nimahaghighatjahromi comparisonofimmunohistochemicalexpressionofcd10inkeratocysticodontogenictumorandameloblastoma AT foroozkeshani comparisonofimmunohistochemicalexpressionofcd10inkeratocysticodontogenictumorandameloblastoma |
_version_ |
1725123216576348160 |