What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic...
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doaj-c71505059abf4607b767f3a3dd0a52592020-11-25T03:31:01ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10476.111289What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]Sarah Martin0Ahmad Al Khleifat1Ammar Al-Chalabi2Maurice Wohl Clinical Neuroscience Institute, King’s College, London, UKMaurice Wohl Clinical Neuroscience Institute, King’s College, London, UKMaurice Wohl Clinical Neuroscience Institute, King’s College, London, UKAmyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis are only partly known, but they include some environmental risk factors as well as several genes that have been identified as harbouring disease-associated variation. Here we review the nature, epidemiology, genetic associations, and environmental exposures associated with amyotrophic lateral sclerosis.https://f1000research.com/articles/6-371/v1Medical GeneticsMotor SystemsMultiple Sclerosis & Related DisordersNeurobiology of Disease & RegenerationNeurogeneticsOccupational & Environmental MedicineSocial & Behavioral Determinants of Health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah Martin Ahmad Al Khleifat Ammar Al-Chalabi |
spellingShingle |
Sarah Martin Ahmad Al Khleifat Ammar Al-Chalabi What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] F1000Research Medical Genetics Motor Systems Multiple Sclerosis & Related Disorders Neurobiology of Disease & Regeneration Neurogenetics Occupational & Environmental Medicine Social & Behavioral Determinants of Health |
author_facet |
Sarah Martin Ahmad Al Khleifat Ammar Al-Chalabi |
author_sort |
Sarah Martin |
title |
What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
title_short |
What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
title_full |
What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
title_fullStr |
What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
title_full_unstemmed |
What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
title_sort |
what causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2017-03-01 |
description |
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis are only partly known, but they include some environmental risk factors as well as several genes that have been identified as harbouring disease-associated variation. Here we review the nature, epidemiology, genetic associations, and environmental exposures associated with amyotrophic lateral sclerosis. |
topic |
Medical Genetics Motor Systems Multiple Sclerosis & Related Disorders Neurobiology of Disease & Regeneration Neurogenetics Occupational & Environmental Medicine Social & Behavioral Determinants of Health |
url |
https://f1000research.com/articles/6-371/v1 |
work_keys_str_mv |
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