Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

Terfenadine (4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-(4-tert-butylphenyl)-butan-1-ol) was identified in a biological screening to be a moderate inhibitor (27% inhibition) of the CD81-LEL–HCV-E2 interaction. To increase the observed biologicalactivity, 63 terfenadine derivates were synthesiz...

Full description

Bibliographic Details
Main Authors: Rolf W. Hartmann, Christian D. Klein, Lars Kattner, Ralf Bartenschlager, Artur Kaul, Bernd Kronenberger, Beatrice Albrecht, Sigrid Ziegler, Marcel Holzer
Format: Article
Language:English
Published: MDPI AG 2008-05-01
Series:Molecules
Subjects:
Hepatitis C Virus
CD81-receptor
large extracellular loop
terfenadine derivatives
microwave assisted syntheses.
Online Access:http://www.mdpi.com/1420-3049/13/5/1081/

Internet

http://www.mdpi.com/1420-3049/13/5/1081/

Similar Items