Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey
Introduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association betw...
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Online Access: | http://dx.doi.org/10.1155/2021/4688900 |
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doaj-c72d1c7c652944d0bdfc4e7870a844f82021-10-04T01:58:39ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/4688900Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination SurveyLu Hao0Qiuyan Chen1Xi Chen2Qing Zhou3Science and Education DepartmentScience and Education DepartmentCentral LaboratoryCentral LaboratoryIntroduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. Methods. We used the data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The multivariable linear regression model was used to examine the association between total bilirubin concentration and telomere length. The nonlinear relationship was analyzed using a generalized additive model with the smoothing plot. Results. A total of 7818 participants with a mean age of 49.20±18.82 years were included. Compared with the lowest concentration of total bilirubin (Q1), the highest quartile of total bilirubin concentration was associated with longer telomere length in male (β=0.04, 95 CI%: 0.00, 0.07, P=0.024) and female (β=0.04, 95 CI%: 0.02, 0.04, P=0.002). Furthermore, an inverted U-shaped relationship between total bilirubin and telomere length was found. On the left of turning points (total bilirubin<0.5 mg/dL), total bilirubin concentration was positively associated with telomere length (β=0.23, 95 CI%: 0.14, 0.32, P<0.001). However, the association between total bilirubin concentration and telomere length was not significant (β=0.01, 95% CI: -0.01, 0.04, P=0.346) above the turning point. Conclusion. This is the first evidence based on a nationally representative survey demonstrating a positive and nonlinear association between total bilirubin concentration and telomere length. Future large-scale prospective studies are warranted to confirm our findings.http://dx.doi.org/10.1155/2021/4688900 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lu Hao Qiuyan Chen Xi Chen Qing Zhou |
spellingShingle |
Lu Hao Qiuyan Chen Xi Chen Qing Zhou Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey Oxidative Medicine and Cellular Longevity |
author_facet |
Lu Hao Qiuyan Chen Xi Chen Qing Zhou |
author_sort |
Lu Hao |
title |
Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey |
title_short |
Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey |
title_full |
Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey |
title_fullStr |
Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey |
title_full_unstemmed |
Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey |
title_sort |
association of serum total bilirubin concentration with telomere length: the national health and nutrition examination survey |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Introduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. Methods. We used the data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The multivariable linear regression model was used to examine the association between total bilirubin concentration and telomere length. The nonlinear relationship was analyzed using a generalized additive model with the smoothing plot. Results. A total of 7818 participants with a mean age of 49.20±18.82 years were included. Compared with the lowest concentration of total bilirubin (Q1), the highest quartile of total bilirubin concentration was associated with longer telomere length in male (β=0.04, 95 CI%: 0.00, 0.07, P=0.024) and female (β=0.04, 95 CI%: 0.02, 0.04, P=0.002). Furthermore, an inverted U-shaped relationship between total bilirubin and telomere length was found. On the left of turning points (total bilirubin<0.5 mg/dL), total bilirubin concentration was positively associated with telomere length (β=0.23, 95 CI%: 0.14, 0.32, P<0.001). However, the association between total bilirubin concentration and telomere length was not significant (β=0.01, 95% CI: -0.01, 0.04, P=0.346) above the turning point. Conclusion. This is the first evidence based on a nationally representative survey demonstrating a positive and nonlinear association between total bilirubin concentration and telomere length. Future large-scale prospective studies are warranted to confirm our findings. |
url |
http://dx.doi.org/10.1155/2021/4688900 |
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