Current Approaches to PANS/PANDAS Diagnostics and Management

• Main Authors: Inna A. Kostik, Mikhail M. Kostik
• Format: Article
• Language: English
• Published: "Paediatrician" Publishers LLC 2020-01-01
• Series: Voprosy Sovremennoj Pediatrii
• Subjects: children; pandas; pans; cans; pitand; obsessive-compulsive syndrome; tic; hyperkinesis; streptococcus; etiology; diagnostics; management
• Online Access: https://vsp.spr-journal.ru/jour/article/view/2230

PANS, or Pediatric Acute-onset Neuropsychiatric Syndrome, is characterized by the sudden onset of obsessive-compulsive syndrome and accompanied by anxiety, emotional lability and other symptoms. PANDAS, or Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections, is a subtype of PANS. Modern data on PANS/PANDAS etiology, pathogenesis, diagnostics and management is presented in this article. Therapeutic decisions on using anti-inflammatory and immunotropic therapy including non-steroidal anti-inflammatory drugs, glucocorticoids, intravenous immunoglobulin, plasmapheresis, rituximab and mycophenolate mofetil are analysed.