Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt

Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt

Two fluorescent streptocyanine labelled oligonucleotides have been synthesized by a simple “click” reaction between a non-fluorescent hemicarboxonium salt and aminoalkyl functionalized thymidines within the oligonucleotide and their spectrophotometric properties have been studied.

Bibliographic Details
Main Authors: Corinne Payrastre, Jean-Marc Escudier, Andreea Muntean, Kristie Lapin, Marie-Pierre Maether
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
nucleotides
modified analogues
diagnostic potentialities
Online Access:http://www.mdpi.com/1420-3049/18/10/12966
Description
Summary:Two fluorescent streptocyanine labelled oligonucleotides have been synthesized by a simple “click” reaction between a non-fluorescent hemicarboxonium salt and aminoalkyl functionalized thymidines within the oligonucleotide and their spectrophotometric properties have been studied.
ISSN:1420-3049

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