Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts

Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts

Abstract Objective Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas characterized by high recurrence rates and early metastases. These tumors arise more frequently within neurofibromatosis type 1 (NF1) and present with resistance during standard chemotherapy leading to increa...

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Bibliographic Details
Main Authors: Susan Fischer-Huchzermeyer, Levan Chikobava, Verena Stahn, Monique Zangarini, Philip Berry, Gareth J. Veal, Volker Senner, Victor F. Mautner, Anja Harder
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Research Notes
Subjects:
Malignant peripheral nerve sheath tumors (MPNST)
Neurofibromatosis type 1 (NF1)
Nude mouse model
All-trans retinoic acid (ATRA)
MEK inhibitor (MEKi)
S462
Online Access:http://link.springer.com/article/10.1186/s13104-018-3630-0

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