Water transport through rat colonic epithelium during ceftriaxone therapy

Water transport through rat colonic epithelium during ceftriaxone therapy

The dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both dose...

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Main Authors: T. Dovbynchuk, T. Beregova, H. Tolstanova, L. Zakordonets
Format: Article
Language:English
Published: Taras Shevchenko National University of Kyiv 2016-07-01
Series:Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
Subjects:
colon, ceftriaxone, diarrhea
Online Access:http://biovestnik.com/index.php/biology/article/view/24
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spelling doaj-c74dab2ebf6e409ebba5b1b32e0a94582020-11-24T20:52:21ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362016-07-01683293310.17721/1728_2748.2014.68.29-3324Water transport through rat colonic epithelium during ceftriaxone therapyT. Dovbynchuk0T. Beregova1H. Tolstanova2L. Zakordonets3Taras Shevchenko National University of Kyiv, KyivTaras Shevchenko National University of Kyiv, KyivTaras Shevchenko National University of Kyiv, KyivO.O. Bogomolets National Medical University, KyivThe dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both doses decreased net water absorption in rat colon. The resulting effect was more pronounced after 14-days course compared with 5-days.http://biovestnik.com/index.php/biology/article/view/24colon, ceftriaxone, diarrhea
collection DOAJ
language English
format Article
sources DOAJ
author T. Dovbynchuk
T. Beregova
H. Tolstanova
L. Zakordonets
spellingShingle T. Dovbynchuk
T. Beregova
H. Tolstanova
L. Zakordonets
Water transport through rat colonic epithelium during ceftriaxone therapy
Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
colon, ceftriaxone, diarrhea
author_facet T. Dovbynchuk
T. Beregova
H. Tolstanova
L. Zakordonets
author_sort T. Dovbynchuk
title Water transport through rat colonic epithelium during ceftriaxone therapy
title_short Water transport through rat colonic epithelium during ceftriaxone therapy
title_full Water transport through rat colonic epithelium during ceftriaxone therapy
title_fullStr Water transport through rat colonic epithelium during ceftriaxone therapy
title_full_unstemmed Water transport through rat colonic epithelium during ceftriaxone therapy
title_sort water transport through rat colonic epithelium during ceftriaxone therapy
publisher Taras Shevchenko National University of Kyiv
series Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
issn 1728-2748
2308-8036
publishDate 2016-07-01
description The dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both doses decreased net water absorption in rat colon. The resulting effect was more pronounced after 14-days course compared with 5-days.
topic colon, ceftriaxone, diarrhea
url http://biovestnik.com/index.php/biology/article/view/24
work_keys_str_mv AT tdovbynchuk watertransportthroughratcolonicepitheliumduringceftriaxonetherapy
AT tberegova watertransportthroughratcolonicepitheliumduringceftriaxonetherapy
AT htolstanova watertransportthroughratcolonicepitheliumduringceftriaxonetherapy
AT lzakordonets watertransportthroughratcolonicepitheliumduringceftriaxonetherapy
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