Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting...
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doaj-c762682505234dd990700e007aac336b2020-11-24T22:23:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-04-01910.3389/fphar.2018.00428345820Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A ReviewDongqing Guo0Colin E. Murdoch1Tianhua Liu2Jia Qu3Shihong Jiao4Yong Wang5Wei Wang6Xing Chen7School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United KingdomSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Information and Control Engineering, China University of Mining and Technology, Xuzhou, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Information and Control Engineering, China University of Mining and Technology, Xuzhou, ChinaIschemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented.http://journal.frontiersin.org/article/10.3389/fphar.2018.00428/fullischemic heart diseasetreatment statusChinese herbal medicinestherapeutic angiogenesistargets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dongqing Guo Colin E. Murdoch Tianhua Liu Jia Qu Shihong Jiao Yong Wang Wei Wang Xing Chen |
spellingShingle |
Dongqing Guo Colin E. Murdoch Tianhua Liu Jia Qu Shihong Jiao Yong Wang Wei Wang Xing Chen Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review Frontiers in Pharmacology ischemic heart disease treatment status Chinese herbal medicines therapeutic angiogenesis targets |
author_facet |
Dongqing Guo Colin E. Murdoch Tianhua Liu Jia Qu Shihong Jiao Yong Wang Wei Wang Xing Chen |
author_sort |
Dongqing Guo |
title |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review |
title_short |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review |
title_full |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review |
title_fullStr |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review |
title_full_unstemmed |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review |
title_sort |
therapeutic angiogenesis of chinese herbal medicines in ischemic heart disease: a review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-04-01 |
description |
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented. |
topic |
ischemic heart disease treatment status Chinese herbal medicines therapeutic angiogenesis targets |
url |
http://journal.frontiersin.org/article/10.3389/fphar.2018.00428/full |
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