Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives

Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives

Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were...

Full description

Bibliographic Details
Main Authors: Jun-Rong Jiang, Feng Xu, Han-Gui Wu
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2016/4617454
id doaj-c762b52d5b444ef998e8b728e1866215
record_format Article
spelling doaj-c762b52d5b444ef998e8b728e18662152020-11-24T22:23:53ZengHindawi LimitedJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/46174544617454Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione DerivativesJun-Rong Jiang0Feng Xu1Han-Gui Wu2Chemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaChemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaChemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaSeveral new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.http://dx.doi.org/10.1155/2016/4617454
collection DOAJ
language English
format Article
sources DOAJ
author Jun-Rong Jiang
Feng Xu
Han-Gui Wu
spellingShingle Jun-Rong Jiang
Feng Xu
Han-Gui Wu
Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
Journal of Chemistry
author_facet Jun-Rong Jiang
Feng Xu
Han-Gui Wu
author_sort Jun-Rong Jiang
title Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
title_short Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
title_full Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
title_fullStr Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
title_full_unstemmed Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
title_sort synthesis and anticancer activity of 1-(1h-indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione derivatives
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2016-01-01
description Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.
url http://dx.doi.org/10.1155/2016/4617454
work_keys_str_mv AT junrongjiang synthesisandanticanceractivityof11hindol3yl24diarylmethylpiperazine1ylethane12dionederivatives
AT fengxu synthesisandanticanceractivityof11hindol3yl24diarylmethylpiperazine1ylethane12dionederivatives
AT hanguiwu synthesisandanticanceractivityof11hindol3yl24diarylmethylpiperazine1ylethane12dionederivatives
_version_ 1725763431529709568

Similar Items