Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients
Introduction & Objective: Diabetes mellitus is a common disease that almost 1.5 million people in Iran are affected, Regarding to the adverse effects of chemical drugs, the tendency to use medicinal plants, among which nettle was chosen to be studied, is growing. In this research the effect of h...
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Hamadan University of Medical Sciences
2012-03-01
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doaj-c764fdc0e3da42c5bb67a28e52b7b5052020-11-25T04:04:00ZfasHamadan University of Medical Sciencesپزشکی بالینی ابن سینا2588-722X2588-72382012-03-011841014Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic PatientsNazli Namazi0Ali Tarighat Esfanjani1Masoud Avari2Javad Heshmati3 Introduction & Objective: Diabetes mellitus is a common disease that almost 1.5 million people in Iran are affected, Regarding to the adverse effects of chemical drugs, the tendency to use medicinal plants, among which nettle was chosen to be studied, is growing. In this research the effect of hydroalcoholic extract of nettle on insulin sensitivity and some inflammatory factors in type II diabetic patients were studied. Materials & Methods: A blind randomized clinical trial on 50 men and women with type 2 diabetes (mean age: 52.39±13.75) was designed to determine the aforementioned effect. Patients were randomly divided into intervention and control groups who received 100 mg/kg, Nettle extract or placebo respectively three times a day for 8 weeks. Fasting Insulin and some inflammatory factors (Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), and hsCRP (High Sensitive C-Reactive Protein) levels at the beginning and end of the study were measured. Results: IL-6 and hsCRP showed a significant decrease (P <0.05), TNF-α, insulin sensitivity and hsCRP showed no significant change at the end of the study in the intervention group compared to the control. Statistical analysis was performed with SPSS software version 18 and P <0.05 was considered significant for all measurements. Conclusion: The hydroalcoholic extract of nettle showed significant decrease in IL-6 and hsCRP after 2 months of intervention in patients with type 2 diabetes.http://sjh.umsha.ac.ir/article-1-207-en.htmldiabetes mellitustype 2inflammationinsulinnettle |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Nazli Namazi Ali Tarighat Esfanjani Masoud Avari Javad Heshmati |
spellingShingle |
Nazli Namazi Ali Tarighat Esfanjani Masoud Avari Javad Heshmati Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients پزشکی بالینی ابن سینا diabetes mellitus type 2 inflammation insulin nettle |
author_facet |
Nazli Namazi Ali Tarighat Esfanjani Masoud Avari Javad Heshmati |
author_sort |
Nazli Namazi |
title |
Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients |
title_short |
Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients |
title_full |
Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients |
title_fullStr |
Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients |
title_full_unstemmed |
Effects of Hydroalcoholic Nettle Extract on Insulin Sensitivity and Some Inflammatory Indicator in type 2 Diabetic Patients |
title_sort |
effects of hydroalcoholic nettle extract on insulin sensitivity and some inflammatory indicator in type 2 diabetic patients |
publisher |
Hamadan University of Medical Sciences |
series |
پزشکی بالینی ابن سینا |
issn |
2588-722X 2588-7238 |
publishDate |
2012-03-01 |
description |
Introduction & Objective: Diabetes mellitus is a common disease that almost 1.5 million people in Iran are affected, Regarding to the adverse effects of chemical drugs, the tendency to use medicinal plants, among which nettle was chosen to be studied, is growing. In this research the effect of hydroalcoholic extract of nettle on insulin sensitivity and some inflammatory factors in type II diabetic patients were studied.
Materials & Methods: A blind randomized clinical trial on 50 men and women with type 2 diabetes (mean age: 52.39±13.75) was designed to determine the aforementioned effect. Patients were randomly divided into intervention and control groups who received 100 mg/kg, Nettle extract or placebo respectively three times a day for 8 weeks. Fasting Insulin and some inflammatory factors (Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), and hsCRP (High Sensitive C-Reactive Protein) levels at the beginning and end of the study were measured.
Results: IL-6 and hsCRP showed a significant decrease (P <0.05), TNF-α, insulin sensitivity and hsCRP showed no significant change at the end of the study in the intervention group compared to the control. Statistical analysis was performed with SPSS software version 18 and P <0.05 was considered significant for all measurements.
Conclusion: The hydroalcoholic extract of nettle showed significant decrease in IL-6 and hsCRP after 2 months of intervention in patients with type 2 diabetes. |
topic |
diabetes mellitus type 2 inflammation insulin nettle |
url |
http://sjh.umsha.ac.ir/article-1-207-en.html |
work_keys_str_mv |
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