Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia
Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (SN). However, few studies have investigated regions outside the SN, fewer have measured levels of multiple metals across differ...
Main Authors: | Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
|
Series: | Frontiers in Aging Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.641222/full |
Similar Items
-
Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
by: Melissa Scholefield, et al.
Published: (2021-08-01) -
Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain
by: Melissa Scholefield, et al.
Published: (2020-10-01) -
Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes
by: Mercedes Lachén-Montes, et al.
Published: (2021-06-01) -
Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
by: Miguel Germán Borda, et al.
Published: (2019-04-01) -
Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
by: Kurt A. Jellinger, et al.
Published: (2018-03-01)