Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method
Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The opti...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | Journal of Nanomaterials |
Online Access: | http://dx.doi.org/10.1155/2017/3282693 |
id |
doaj-c7720580b7fd4187910dd4050ec5449d |
---|---|
record_format |
Article |
spelling |
doaj-c7720580b7fd4187910dd4050ec5449d2020-11-24T23:41:11ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292017-01-01201710.1155/2017/32826933282693Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification MethodPey-Shiuan Wu0Chih-Hung Lin1Yi-Ching Kuo2Chih-Chien Lin3Department of Cosmetic Science, Providence University, Taichung, TaiwanDepartment of Cosmetic Science, Providence University, Taichung, TaiwanDepartment of Cosmetic Science, Providence University, Taichung, TaiwanDepartment of Cosmetic Science, Providence University, Taichung, TaiwanNanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was 393.30±28.23 nm and the encapsulation efficiency was 22.13±2.66%. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future.http://dx.doi.org/10.1155/2017/3282693 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pey-Shiuan Wu Chih-Hung Lin Yi-Ching Kuo Chih-Chien Lin |
spellingShingle |
Pey-Shiuan Wu Chih-Hung Lin Yi-Ching Kuo Chih-Chien Lin Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method Journal of Nanomaterials |
author_facet |
Pey-Shiuan Wu Chih-Hung Lin Yi-Ching Kuo Chih-Chien Lin |
author_sort |
Pey-Shiuan Wu |
title |
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method |
title_short |
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method |
title_full |
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method |
title_fullStr |
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method |
title_full_unstemmed |
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method |
title_sort |
formulation and characterization of hydroquinone nanostructured lipid carriers by homogenization emulsification method |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2017-01-01 |
description |
Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was 393.30±28.23 nm and the encapsulation efficiency was 22.13±2.66%. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future. |
url |
http://dx.doi.org/10.1155/2017/3282693 |
work_keys_str_mv |
AT peyshiuanwu formulationandcharacterizationofhydroquinonenanostructuredlipidcarriersbyhomogenizationemulsificationmethod AT chihhunglin formulationandcharacterizationofhydroquinonenanostructuredlipidcarriersbyhomogenizationemulsificationmethod AT yichingkuo formulationandcharacterizationofhydroquinonenanostructuredlipidcarriersbyhomogenizationemulsificationmethod AT chihchienlin formulationandcharacterizationofhydroquinonenanostructuredlipidcarriersbyhomogenizationemulsificationmethod |
_version_ |
1725507901737402368 |