Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the exact molecular mechanism of schwannoma development is still...

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Bibliographic Details
Main Authors:	Zhiguo Chen, Stephen Li, Juan Mo, Eric Hawley, Yong Wang, Yongzheng He, Jean-Philippe Brosseau, Tracey Shipman, D. Wade Clapp, Thomas J. Carroll, Lu Q. Le
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2020-10-01
Series:	JCI Insight
Subjects:	Genetics Oncology
Online Access:	https://doi.org/10.1172/jci.insight.141514

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