Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways

Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways

Myocardial ischemia-reperfusion injury (IRI) is a severe trauma which is characterized by inflammatory reaction, oxidative stress and cardiomyocyte apoptosis. Anesthetics such as sevoflurane have been proved to exhibit cardioprotective effect on IRI and the present study aimed to explore the underly...

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Bibliographic Details
Main Authors: Wensheng Zhao, Tieshan Zhang, Lulu Xu, Yue Yang, Yingchao Wang, Zhenni Jiang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Biotechnology & Biotechnological Equipment
Subjects:
sevoflurane
hypoxia/reoxygenation injury
apoptosis
akt/pim-1
akt/gsk3β
Online Access:http://dx.doi.org/10.1080/13102818.2019.1688685

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