The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia
Aim. To give the preliminary results of the AML-01.10 Russian multicenter randomized trial to treat adult acute myeloid leukemia (AML), the basic principle of which is to use high-dose anthracycline antibiotics in induction/consolidation. Subjects and methods. By December 2011, 145 patients with AML...
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"Consilium Medicum" Publishing house
2012-07-01
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doaj-c77c99fdac7d42888f68046117c448a42020-11-25T03:22:54Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422012-07-01847101528052The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of RussiaE N ParovichnikovaG A KliasovaA N SokolovV V TroitskaiaA V KokhnoL A Kuz'mina1I I ShaforostovaV V RyzhkoS K KravchenkoS N BondarenkoV A LapinA S PristupaT S KonstantinovaT P ZagoskinaI V IalykomovV I MoskovL V AnchukovaT S KaporskaiaE M VolodichevaK D KaplanovE V KondakovaO S SamoĭlovaL V GavrilovaS M Kulikov1V G SavchenkoAim. To give the preliminary results of the AML-01.10 Russian multicenter randomized trial to treat adult acute myeloid leukemia (AML), the basic principle of which is to use high-dose anthracycline antibiotics in induction/consolidation. Subjects and methods. By December 2011, 145 patients with AML had been randomized from 18 hematology centers of 15 cities and towns of the Russian Federation; the median age of all the patients was 44 years. Seventy-one patients were analyzed in August 2011 (a 1.5-year follow-up). Results. The efficiency of 2 courses 7+3 using high-dose daunorubicin (60 mg/m2 per administration) and continuous infusion of cytarabine during the second course was high and comparable with that in the use of a high-dose HAM protocol as a second induction course and can achieve a complete remission in 74.6%. The protocol toxicity evaluated from its early mortality (11.3%) and its death in complete remission (16.6%) was permissible, particularly by taking into consideration the multicenter pattern of the trial. At the completion of analysis, 53 (68.8%) out of the 77 patients on whom the data on their vital status were available were alive. In this follow-up period, the frequency of recurrences was 19.2% (10/52). Only 3 (4.2%) patients out of the 71 patients in whom the efficiency of the protocol had been completely evaluated underwent allogeneic bone marrow transplantation. Conclusion. The total high dose (720 mg/m2) of anthracycline antibiotics, which is used in the period of induction and consolidation, determines the long periods of myelosuppression and intercourse intervals. Protocol deviations (no course of consolidation therapy, lower-dose idarubicin during consolidation therapy, a course of low-dose cytarabine between the courses of induction and consolidation chemotherapy, and very long intercourse intervals) were recorded in a total of 20 (28%) patients.https://ter-arkhiv.ru/0040-3660/article/view/31036results of the aml-01.10 protocolhigh-dose anthracycline antibiotic |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E N Parovichnikova G A Kliasova A N Sokolov V V Troitskaia A V Kokhno L A Kuz'mina1 I I Shaforostova V V Ryzhko S K Kravchenko S N Bondarenko V A Lapin A S Pristupa T S Konstantinova T P Zagoskina I V Ialykomov V I Moskov L V Anchukova T S Kaporskaia E M Volodicheva K D Kaplanov E V Kondakova O S Samoĭlova L V Gavrilova S M Kulikov1 V G Savchenko |
spellingShingle |
E N Parovichnikova G A Kliasova A N Sokolov V V Troitskaia A V Kokhno L A Kuz'mina1 I I Shaforostova V V Ryzhko S K Kravchenko S N Bondarenko V A Lapin A S Pristupa T S Konstantinova T P Zagoskina I V Ialykomov V I Moskov L V Anchukova T S Kaporskaia E M Volodicheva K D Kaplanov E V Kondakova O S Samoĭlova L V Gavrilova S M Kulikov1 V G Savchenko The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia Терапевтический архив results of the aml-01.10 protocol high-dose anthracycline antibiotic |
author_facet |
E N Parovichnikova G A Kliasova A N Sokolov V V Troitskaia A V Kokhno L A Kuz'mina1 I I Shaforostova V V Ryzhko S K Kravchenko S N Bondarenko V A Lapin A S Pristupa T S Konstantinova T P Zagoskina I V Ialykomov V I Moskov L V Anchukova T S Kaporskaia E M Volodicheva K D Kaplanov E V Kondakova O S Samoĭlova L V Gavrilova S M Kulikov1 V G Savchenko |
author_sort |
E N Parovichnikova |
title |
The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia |
title_short |
The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia |
title_full |
The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia |
title_fullStr |
The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia |
title_full_unstemmed |
The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia |
title_sort |
first results of treatment for adult acute myeloid leukemia according to the aml-01.10 protocol of the research group of the hematology centers of russia |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2012-07-01 |
description |
Aim. To give the preliminary results of the AML-01.10 Russian multicenter randomized trial to treat adult acute myeloid leukemia (AML), the basic principle of which is to use high-dose anthracycline antibiotics in induction/consolidation. Subjects and methods. By December 2011, 145 patients with AML had been randomized from 18 hematology centers of 15 cities and towns of the Russian Federation; the median age of all the patients was 44 years. Seventy-one patients were analyzed in August 2011 (a 1.5-year follow-up). Results. The efficiency of 2 courses 7+3 using high-dose daunorubicin (60 mg/m2 per administration) and continuous infusion of cytarabine during the second course was high and comparable with that in the use of a high-dose HAM protocol as a second induction course and can achieve a complete remission in 74.6%. The protocol toxicity evaluated from its early mortality (11.3%) and its death in complete remission (16.6%) was permissible, particularly by taking into consideration the multicenter pattern of the trial. At the completion of analysis, 53 (68.8%) out of the 77 patients on whom the data on their vital status were available were alive. In this follow-up period, the frequency of recurrences was 19.2% (10/52). Only 3 (4.2%) patients out of the 71 patients in whom the efficiency of the protocol had been completely evaluated underwent allogeneic bone marrow transplantation. Conclusion. The total high dose (720 mg/m2) of anthracycline antibiotics, which is used in the period of induction and consolidation, determines the long periods of myelosuppression and intercourse intervals. Protocol deviations (no course of consolidation therapy, lower-dose idarubicin during consolidation therapy, a course of low-dose cytarabine between the courses of induction and consolidation chemotherapy, and very long intercourse intervals) were recorded in a total of 20 (28%) patients. |
topic |
results of the aml-01.10 protocol high-dose anthracycline antibiotic |
url |
https://ter-arkhiv.ru/0040-3660/article/view/31036 |
work_keys_str_mv |
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