Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive accumulation of lung fibroblasts (LFs) and collagen in the lung parenchyma. The mechanisms that underlie IPF pathophysiology are thought to reflect repeated alveolar epithelial injury leading to an aberrant wound r...
Main Authors: | Kaj E. C. Blokland, David W. Waters, Michael Schuliga, Jane Read, Simon D. Pouwels, Christopher L. Grainge, Jade Jaffar, Glen Westall, Steven E. Mutsaers, Cecilia M. Prêle, Janette K. Burgess, Darryl A. Knight |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/12/4/389 |
Similar Items
-
A Senescence Bystander Effect in Human Lung Fibroblasts
by: David W. Waters, et al.
Published: (2021-09-01) -
Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM
by: Kaj E. C. Blokland, et al.
Published: (2021-06-01) -
Senescent Cells in IPF: Locked in Repair?
by: Silke Meiners, et al.
Published: (2020-12-01) -
The Paradoxical Role of Cellular Senescence in Cancer
by: Jing Yang, et al.
Published: (2021-08-01) -
Corrigendum: The Paradoxical Role of Cellular Senescence in Cancer
by: Jing Yang, et al.
Published: (2021-09-01)