NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip.

NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip.

Vasopressin increases urine concentration through activation of aquaporin-2 (AQP2) in the collecting duct. Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin E2 synthesis, and may suppress AQP2 producing a urine concentrating defect. There are four serines in AQP2 that are phosphoryla...

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Bibliographic Details
Main Authors: Huiwen Ren, Baoxue Yang, Patrick A Molina, Jeff M Sands, Janet D Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4627840?pdf=render

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