Ligand-Independent EGFR Activation by Anchorage-Stimulated Src Promotes Cancer Cell Proliferation and Cetuximab Resistance via ErbB3 Phosphorylation

Ligand-Independent EGFR Activation by Anchorage-Stimulated Src Promotes Cancer Cell Proliferation and Cetuximab Resistance via ErbB3 Phosphorylation

Activation of the epidermal growth factor receptor (EGFR) pathway plays an important role in the progression of cancer and is associated with a poor prognosis in patients. The monoclonal antibody cetuximab, which displays EGFR extracellular domain-specific binding, has proven effective in the treatm...

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Bibliographic Details
Main Authors: Masami Nozaki, Hiroki Yasui, Yuichi Ohnishi
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
egfr
erbb3
src
phosphorylation
tk inhibitor
cetuximab
Online Access:https://www.mdpi.com/2072-6694/11/10/1552

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