An X-ray and Natural Bond Orbital (NBO) structural study of α-tocopheryl and 2,2,5,7,8-pentamethylchroman-6-yl succinates

An X-ray and Natural Bond Orbital (NBO) structural study of α-tocopheryl and 2,2,5,7,8-pentamethylchroman-6-yl succinates

α-Tocopheryl succinate (α-TOS) is a very promising anticancer agent; however, the mechanism of its action and the role of the succinic moiety in biological activity still remains unclear. This paper, presents the first determination of the X-ray structure of α-TOS and 2,2,5,7,8-pentamethylchroman-6-...

Full description

Bibliographic Details
Main Authors:	Piotr Wałejko, Łukasz Dobrzycki, Artur Ratkiewicz, Paweł Socha, Stanisław Witkowski, Michał K. Cyrański
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	Journal of Saudi Chemical Society
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319610318301029

Similar Items

Hepatocellular carcinomas are promoted by tocopheryl acetate but eliminated by tocopheryl succinate
by: Bryant L. Adams, et al.
Published: (2018-09-01)

Tocopheryl Succinate-Induced Structural Changes in DPPC Liposomes: DSC and ANS Fluorescence Studies
by: Grażyna Neunert, et al.
Published: (2020-06-01)

An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy
by: Song Yi Lee, et al.
Published: (2018-01-01)

Cell Toxicology Study of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS).
by: Muenyi, Clarisse Sornsay
Published: (2005)

Recent developments in d-α-tocopheryl polyethylene glycol-succinate-based nanomedicine for cancer therapy
by: Songwei Tan, et al.
Published: (2017-01-01)

The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?
by: Doaa M. Badr, et al.
Published: (2016-01-01)

α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma
by: Carolina Sánchez-Rodríguez, et al.
Published: (2018-09-01)

Chemo-Immunotherapy of Murine Cancer Using Alpha Tocopheryl Succinate and Non-Matured Dendritic Cells
by: Ramanathapuram, Lalitha
Published: (2006)

Interactions of D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) with Phospholipids in Bilayer and Monolayer domains
by: CHU,KUAN-WEI, et al.
Published: (2016)

Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo
by: Lei X, et al.
Published: (2017-08-01)

Synthesis, Colloidal Characterization and Targetability of Phenylboronic Acid Functionalized α-Tocopheryl Polyethylene Glycol Succinate in Cancer Cells
by: Sanjay Tiwari, et al.
Published: (2020-10-01)

Alpha-tocopheryl succinate (α-TOS) influences cell vitality and enzyme activity in Ehrlich ascites carcinoma cells
by: Stankov Karmen, et al.
Published: (2007-01-01)

Delivery of docetaxel using pH-sensitive liposomes based on D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate: Comparison with PEGylated liposomes
by: Shu Han, et al.
Published: (2019-07-01)

Comparison of α-Tocopherol, α-Tocopherol Acetate, and α-Tocopheryl Polyethylene Glycol Succinate 1000 Absorption by Caco-2 TC7 Intestinal Cells
by: Charlotte Cuerq, et al.
Published: (2021-12-01)

Colloidal Characteristics of KDP Dispersions Adding with Hydrogenated Soybean Lecithin or D-α-Tocopheryl Polyethylene Glycol 1000 Succinate
by: Yu-Mei Lin, et al.
Published: (2014)

Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions
by: Sun DQ, et al.
Published: (2014-07-01)

Behaviors of Ascorbic Acid Derivative/D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) Mixtures: Multitechnique Investigation
by: Cheng-Yan Sie, et al.
Published: (2013)

Development of α-Tocopheryl Succinate (α-TOS)-containing pH sensitive drug delivery system for cancer therapy
by: Kuan-Yi Lee, et al.
Published: (2015)

Micellization of D-α-tocopheryl polyethylene glycol 1000 succinate (TGPS 1000): Thermodynamics and related solute solvent interactions
by: Affandi, M.M, et al.
Published: (2014)

(S)-2-(1H-Imidazol-1-yl)succinic acid
by: Jing-Mei Xiao
Published: (2009-05-01)

Inhibition of vascular smooth muscle cell proliferation of vitamin E derivative 2,2,5,7,8-methyl-6-hydroxychromane in an in vitro and in vivo study
by: Cheng-Ying Hsieh, et al.
Published: (2010)

Correction to: Tan et al., Recent developments in D-α-tocopheryl polyethylene glycol-succinate-based nanomedicine for cancer therapy
Published: (2017-01-01)

Characterization, in Vivo and in Vitro Evaluation of Solid Dispersion of Curcumin Containing d-α-Tocopheryl Polyethylene Glycol 1000 Succinate and Mannitol
by: Im-Sook Song, et al.
Published: (2016-10-01)

Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment
by: Zheng Yi, et al.
Published: (2010-01-01)

Crystal structure of diethyl (E)-2-[(benzofuran-2-yl)methylidene]succinate
by: Marie-Luis Schirmer, et al.
Published: (2015-11-01)

Cell Toxicity and Uptake of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) by Various Cell ines <em>In Vitro</em>.
by: Komguem Kamga, Christelle
Published: (2005)

Paclitaxel-loaded polymeric nanoparticles based on α-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model
by: Juan Riestra-Ayora, et al.
Published: (2021-01-01)

Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells
by: Arehalli S. Manjappa, et al.
Published: (2019-12-01)

Combination Delivery of Alpha-Tocopheryl Succinate and Curcumin Using a GSH-Sensitive Micelle (PAH-SS-PLGA) to Treat Pancreatic Cancer
by: Tilahun Ayane Debele, et al.
Published: (2020-08-01)

Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death.
by: Marco Tomasetti, et al.
Published: (2012-01-01)

Effects of 2,2,5,7,8-Pentamethyl-6-Hydroxy-Chroman(PMC), A Newly Synthesized NFkB Inhibitor, on Endotoxin- Induced Septic Shock in Rats
by: 連國維
Published: (1997)

The effect of honey bee venom on the differentiation potency of D-alpha tocopheryl succinate (vitamin E) on HL-60 promyelocytic leukemia cell line.
by: mohammad Nabiuni, et al.
Published: (2014-01-01)

Development and evaluation of vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical
by: Shen R, et al.
Published: (2016-04-01)

In Vitro Characterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery
by: Adeel Masood Butt, et al.
Published: (2012-01-01)

Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by D-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate
by: Qiao H, et al.
Published: (2017-02-01)

Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system
by: Zhao X, et al.
Published: (2018-12-01)

Molecular packing and lateral interactions of oppositely charged dihexadecyl amphiphilics with D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in bilayer and monolayer domains.
by: CHENG, HSING-FANG, et al.
Published: (2018)

Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier
by: Xin Meng, et al.
Published: (2017-06-01)

Triphenylphosphonium and D-α-tocopheryl polyethylene glycol 1000 succinate-modified, tanshinone IIA-loaded lipid-polymeric nanocarriers for the targeted therapy of myocardial infarction
by: Zhang S, et al.
Published: (2018-07-01)

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles
by: Hao J, et al.
Published: (2017-03-01)