New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determine...

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Bibliographic Details
Main Authors: Mangaladoss Fredimoses, Xuefeng Zhou, Xiuping Lin, Xinpeng Tian, Wen Ai, Junfeng Wang, Shengrong Liao, Juan Liu, Bin Yang, Xianwen Yang, Yonghong Liu
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Marine Drugs
Subjects:
prenylxanthone
Emericella
deep-sea
fungus
Online Access:http://www.mdpi.com/1660-3397/12/6/3190
Description
Summary:Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.
ISSN:1660-3397

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