New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determine...

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Main Authors:	Mangaladoss Fredimoses, Xuefeng Zhou, Xiuping Lin, Xinpeng Tian, Wen Ai, Junfeng Wang, Shengrong Liao, Juan Liu, Bin Yang, Xianwen Yang, Yonghong Liu
Format:	Article
Language:	English
Published:	MDPI AG 2014-05-01
Series:	Marine Drugs
Subjects:	prenylxanthone Emericella deep-sea fungus
Online Access:	http://www.mdpi.com/1660-3397/12/6/3190

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spelling	doaj-c7a8bf887bd64a5284d7505053024ae32020-11-25T01:05:36ZengMDPI AGMarine Drugs1660-33972014-05-011263190320210.3390/md12063190md12063190New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240Mangaladoss Fredimoses0Xuefeng Zhou1Xiuping Lin2Xinpeng Tian3Wen Ai4Junfeng Wang5Shengrong Liao6Juan Liu7Bin Yang8Xianwen Yang9Yonghong Liu10Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaFour new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.http://www.mdpi.com/1660-3397/12/6/3190prenylxanthoneEmericelladeep-seafungus
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mangaladoss Fredimoses Xuefeng Zhou Xiuping Lin Xinpeng Tian Wen Ai Junfeng Wang Shengrong Liao Juan Liu Bin Yang Xianwen Yang Yonghong Liu
spellingShingle	Mangaladoss Fredimoses Xuefeng Zhou Xiuping Lin Xinpeng Tian Wen Ai Junfeng Wang Shengrong Liao Juan Liu Bin Yang Xianwen Yang Yonghong Liu New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240 Marine Drugs prenylxanthone Emericella deep-sea fungus
author_facet	Mangaladoss Fredimoses Xuefeng Zhou Xiuping Lin Xinpeng Tian Wen Ai Junfeng Wang Shengrong Liao Juan Liu Bin Yang Xianwen Yang Yonghong Liu
author_sort	Mangaladoss Fredimoses
title	New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240
title_short	New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240
title_full	New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240
title_fullStr	New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240
title_full_unstemmed	New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240
title_sort	new prenylxanthones from the deep-sea derived fungus emericella sp. scsio 05240
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2014-05-01
description	Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.
topic	prenylxanthone Emericella deep-sea fungus
url	http://www.mdpi.com/1660-3397/12/6/3190
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New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

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