Magnetically driven microfluidics for isolation of circulating tumor cells
Abstract Circulating tumor cells (CTCs) largely contribute to cancer metastasis and show potential prognostic significance in cancer isolation and detection. Miniaturization has progressed significantly in the last decade which in turn enabled the development of several microfluidic systems. The mic...
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Online Access: | https://doi.org/10.1002/cam4.3077 |
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doaj-c7c3fb95b92b452e8b31866be4fbee032020-11-25T02:28:51ZengWileyCancer Medicine2045-76342020-06-019124207423110.1002/cam4.3077Magnetically driven microfluidics for isolation of circulating tumor cellsLaan Luo0Yongqing He1School of Chemical Engineering Kunming University of Science and Technology Kunming ChinaSchool of Chemical Engineering Kunming University of Science and Technology Kunming ChinaAbstract Circulating tumor cells (CTCs) largely contribute to cancer metastasis and show potential prognostic significance in cancer isolation and detection. Miniaturization has progressed significantly in the last decade which in turn enabled the development of several microfluidic systems. The microfluidic systems offer a controlled microenvironment for studies of fundamental cell biology, resulting in the rapid development of microfluidic isolation of CTCs. Due to the inherent ability of magnets to provide forces at a distance, the technology of CTCs isolation based on the magnetophoresis mechanism has become a routine methodology. This historical review aims to introduce two principles of magnetic isolation and recent techniques, facilitating research in this field and providing alternatives for researchers in their study of magnetic isolation. Researchers intend to promote effective CTC isolation and analysis as well as active development of next‐generation cancer treatment. The first part of this review summarizes the primary principles based on positive and negative magnetophoretic isolation and describes the metrics for isolation performance. The second part presents a detailed overview of the factors that affect the performance of CTC magnetic isolation, including the magnetic field sources, functionalized magnetic nanoparticles, magnetic fluids, and magnetically driven microfluidic systems.https://doi.org/10.1002/cam4.3077circulating tumor cellsferrofluidsmagnetic fieldmicrofluidics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laan Luo Yongqing He |
spellingShingle |
Laan Luo Yongqing He Magnetically driven microfluidics for isolation of circulating tumor cells Cancer Medicine circulating tumor cells ferrofluids magnetic field microfluidics |
author_facet |
Laan Luo Yongqing He |
author_sort |
Laan Luo |
title |
Magnetically driven microfluidics for isolation of circulating tumor cells |
title_short |
Magnetically driven microfluidics for isolation of circulating tumor cells |
title_full |
Magnetically driven microfluidics for isolation of circulating tumor cells |
title_fullStr |
Magnetically driven microfluidics for isolation of circulating tumor cells |
title_full_unstemmed |
Magnetically driven microfluidics for isolation of circulating tumor cells |
title_sort |
magnetically driven microfluidics for isolation of circulating tumor cells |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2020-06-01 |
description |
Abstract Circulating tumor cells (CTCs) largely contribute to cancer metastasis and show potential prognostic significance in cancer isolation and detection. Miniaturization has progressed significantly in the last decade which in turn enabled the development of several microfluidic systems. The microfluidic systems offer a controlled microenvironment for studies of fundamental cell biology, resulting in the rapid development of microfluidic isolation of CTCs. Due to the inherent ability of magnets to provide forces at a distance, the technology of CTCs isolation based on the magnetophoresis mechanism has become a routine methodology. This historical review aims to introduce two principles of magnetic isolation and recent techniques, facilitating research in this field and providing alternatives for researchers in their study of magnetic isolation. Researchers intend to promote effective CTC isolation and analysis as well as active development of next‐generation cancer treatment. The first part of this review summarizes the primary principles based on positive and negative magnetophoretic isolation and describes the metrics for isolation performance. The second part presents a detailed overview of the factors that affect the performance of CTC magnetic isolation, including the magnetic field sources, functionalized magnetic nanoparticles, magnetic fluids, and magnetically driven microfluidic systems. |
topic |
circulating tumor cells ferrofluids magnetic field microfluidics |
url |
https://doi.org/10.1002/cam4.3077 |
work_keys_str_mv |
AT laanluo magneticallydrivenmicrofluidicsforisolationofcirculatingtumorcells AT yongqinghe magneticallydrivenmicrofluidicsforisolationofcirculatingtumorcells |
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1724836137406562304 |