1,25-Dihydroxyvitamin D3 Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4

1,25-Dihydroxyvitamin D3 Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4

Background/Aims: We investigated how 1,25-dihydroxyvitamin D3 (1,25D3) inhibits the effects of lipopolysaccharide (LPS) in human aortic endothelial cells. Methods: Cellular signaling was explored by determination of protein abundance with Western blot, measurement of cytosolic Ca2+ concentration and...

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Bibliographic Details
Main Authors:	Won Seok Yang, Jin Ju Kim, Nam Jeong Han, Eun Kyoung Lee, Su-Kil Park
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:	Cellular Physiology and Biochemistry
Subjects:	A disintegrin and metalloprotease 10 1,25-Dihydroxyvitamin D3 Ectodomain shedding Lipopolysaccharide L-type calcium channel Toll-like receptor 4
Online Access:	http://www.karger.com/Article/FullText/475449

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